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SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1499479

A Systematic Review of the Association Between Insulin Resistance Surrogate Indices and Bone Mineral Density

Provisionally accepted
Amirhossein Shirinezhad Amirhossein Shirinezhad 1Alireza Azarboo Alireza Azarboo 1Amirhossein Ghaseminejad-Raeini Amirhossein Ghaseminejad-Raeini 1*Fatemeh Kanaani Nejad Fatemeh Kanaani Nejad 2Negar Zareshahi Negar Zareshahi 1Sheyda Mohtasham Amiri Sheyda Mohtasham Amiri 3Yasamin Tahmasebi Yasamin Tahmasebi 1Amir Human Hoveidaei Amir Human Hoveidaei 4
  • 1 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran
  • 2 Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Iran
  • 3 Department of Medicine, Islamic Azad University Tehran Medical Sciences, Iran, Tehran, Iran
  • 4 Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran

The final, formatted version of the article will be published soon.

    The relationship of insulin resistance with bone mineral density (BMD) remains unclear, offering an opportunity for novel indices to shed light on the matter. The aim of this review was to evaluate the association between surrogate indices of insulin resistance and BMD.A systematic review was conducted to evaluate observational studies that examined the relationship between insulin resistance surrogate indices and BMD in adults. Databases including PubMed, Web of Science, Scopus, and Embase were searched. Quality assessment was performed using Joanna Briggs Institute (JBI) critical appraisal tools.This systematic review included 27 cohorts and cross-sectional studies with 71,525 participants to assess the potential link between insulin resistance surrogate indices like HOMA-IR, HOMA-β, TyG, TyG-BMI, TyG-WtHR, and TyG-WC, along with METS-IR, and VAI, and BMD at various sites. There seems to be no link between BMD and the HOMA index, despite being extensively studied in various studies (adjusted β ranging from -0.49 to 0.103). Most literature suggests that a higher TyG index is associated with decreased BMD levels (adjusted β ranging from -0.085 to 0.0124). Despite limited evidence, other insulin resistance indices such as VAI (adjusted β ranging from 0.007 to 0.016), TyG-BMI (adjusted β ranging from 0.002 to 0.415), METS-IR (adjusted β ranging from 0.005 to 0.060), TyG-WtHR (β = 0.012) and TyG-WC (β = 0.0001) have shown a positive association with BMD in a few studies.This systematic review emphasizes the intricate connection between insulin resistance and BMD.The lack of ability to perform a meta-analysis and the dependence on cross-sectional studies hinder the robustness of the findings, hence necessitating well-designed longitudinal studies.

    Keywords: Insulin Resistance, bone mineral density, HOMA-IR, TyG index, VAI, Systematic review, Osteoporosis, BMD

    Received: 20 Sep 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Shirinezhad, Azarboo, Ghaseminejad-Raeini, Kanaani Nejad, Zareshahi, Amiri, Tahmasebi and Hoveidaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Amirhossein Ghaseminejad-Raeini, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran

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