AUTHOR=Corripio Raquel , Soriano-Guillén Leandro , Herrero Francisco-Javier , Castro-Feijoó Lidia , Escribano Aránzazu , Sol-Ventura Paula , Espino Rafael , Vela Amaia , Labarta José-Ignacio , The Spanish PUBERE Group , Argente Jesús , Díez López Ignacio , Ruiz Cano Rafael , Rosado José Pastor , Sotto Diego Esteban de , Perez Nuria Cabrinety , Fernández Diego Yeste , Suárez Ortega Larisa , Alcaina Mariona Bonet , Ramos Rosa Martín , Aromir Gertrudis Martí , Tomasini Rosangela , González Gemma Carreras , Borrás Pérez María Victoria , Rodas Meritxell Torrabías , Sureda Montserrat Roqueta , Valles Marta Murillo , Díez Francisco Javier Arroyo , de Buitrago Jesús González , Campoy José Luis Lechuga , Sancho Alfonso Lechuga , Estrada Ramón Cañete , Feijóo Lidia Castro , Conde Jesús Barreiro , Rodríguez Paloma Cabanas , Muñoz Jordi Bosch , Cepedano Dans Alicia , Calvo Mª Teresa Muñoz , Fernández Julio Guerrero , Matarranz Rafael Yturriaga , Gómez Elena Gallego , del Pozo Jaime Sánchez , Pérez Purificación Ros , Fernández Joaquín Ramírez , Arnao Mª Dolores Rodríguez , Sánchez Amparo Rodríguez , Siguero Juan Pedro López , Ollero Maria Jose Martinez-Aedo , Macias Antonio Gutiérrez , Tello José María Martos , Guindulain María Chueca , Sanjulián Cristina Azcona , Guerrero Pablo , Galán Isolina Riaño , González Sofía Quinteiro , Rodríguez José Manuel Rial , Díaz Juan Pedro González , Aguilar Rafael Espino , López-Canti Luis , Gelonch Raquel Monné , Calama Jesús Martín , Gonzalez Lidia Blasco , SáezJosé Juan Alcón , Couchoud Amparo Plasencia , González Luis Castaño , Tobío Pedro Martul , Etxebarría Itxaso Rica , Ramos Concepción Fernández , Gracia Mª. Zaragoza Lou Francés , Zalaya Manuel Ruiz-Echarri , Lozano Gloria Bueno TITLE=Adult height in girls with idiopathic central precocious puberty treated with triptorelin JOURNAL=Frontiers in Endocrinology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1498726 DOI=10.3389/fendo.2024.1498726 ISSN=1664-2392 ABSTRACT=Objective

Idiopathic central precocious puberty (CPP) precipitates epiphyseal fusion of growth plates in long bones, leading to reduced adult stature. Gonadotropin-releasing hormone analogues (GnRHa) are the treatment of choice for idiopathic CPP, but their benefit on height gain is unclear. We aimed to elucidate the effects of GnRHa treatment on adult height in girls with idiopathic CPP.

Design

This prospective observational descriptive study analyzed data of girls with idiopathic CPP diagnosed at 55 centers in Spain between January 1, 1998 and December 31, 2012 included in the Spanish Society for Pediatric Endocrinology’s national registry.

Methods

We included girls with idiopathic CPP (thelarche < 8 years, positive LHRH stimulation test, bone age > 1 year older than chronological age, and normal brain imaging) treated with triptorelin (3.75 mg monthly, adjusted according to LHRH test results and clinical findings). We assessed weight, height, BMI, and secondary sexual characteristics every 6 months and bone age every 12 months until adult height (AH) was attained. The primary outcome was the difference between AH and target height (TH).

Results

A total of 465 girls (18.90% adopted) were included; we analyzed data recorded at treatment end in 358 girls and at AH in 216. Mean difference between AH and TH was -1.5 (95%CI: -2.56− -0.45) cm and between AH and PAH 2,57 (95%CI:-3.56− -1.58) cm.

Conclusions

GnRHa treatment helps preserve genetic growth potential in girls with idiopathic CPP.