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PERSPECTIVE article
Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1492753
Is choline kinase alpha a drug target for obesity?
Provisionally accepted- 1 Sols-Morreale Biomedical Research Institute (IIBM), Faculty of Medicine, Autonomous University of Madrid, Madrid, Madrid, Spain
- 2 Instituto de Investigaciones Biomédicas, Madrid, Spain
- 3 North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States
- 4 High Point University, High Point, United States
Choline kinase alpha (ChoK) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a larger variety of conditions.Here we present our working model for how ChoK could play a role in obesity and for how drugs being developed as therapeutics for other diseases using ChoK as a target, could be repurposed as prophylactic treatments for obesity. We also present preliminary observations in support of our model.
Keywords: Choline, Choline Kinase, Thermogenesis, Adipogenesis, Obesity
Received: 07 Sep 2024; Accepted: 15 Oct 2024.
Copyright: © 2024 Lacal, Ibrahim and Zimmerman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juan Carlos Lacal, Sols-Morreale Biomedical Research Institute (IIBM), Faculty of Medicine, Autonomous University of Madrid, Madrid, 28029, Madrid, Spain
Salam A. Ibrahim, Instituto de Investigaciones Biomédicas, Madrid, Spain
Tahl Zimmerman, High Point University, High Point, United States
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