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REVIEW article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1492610

Mechanism and application prospect of ferroptosis inhibitors in improving osteoporosis

Provisionally accepted
Jing Wang Jing Wang Ting Rui Chen Ting Rui Chen Fei Gao Fei Gao *
  • First Hospital of Shanxi Medical University, Taiyuan, Shaanxi, China

The final, formatted version of the article will be published soon.

    Osteoporosis, a prevalent bone metabolic disorder, has emerged as a pressing global public health concern. Recent studies have illuminated a crucial link between ferroptosis and the pathogenesis of osteoporosis. Nevertheless, the intricate mechanisms underlying the role of ferroptosis in this condition remain largely unexplored. Therefore, this article comprehensively reviews the regulatory mechanisms of ferroptosis and the modulating effects on the development and progression of osteoporosis, as reported in recent years. Furthermore, this review summarizes the current state of the interventional strategies employed by both Western medicines and traditional Chinese medicines (TCMs) in addressing osteoporosis. This review aims to uncover potential novel avenues for the prevention and control of osteoporosis by synthesizing the modes of action and clinical efficacy of these therapeutic modalities.

    Keywords: Ferroptosis1, osteoporosis2, lipid peroxidation3, iron overload4, Western medicines5, traditional Chinese medicines6

    Received: 07 Sep 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Wang, Chen and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fei Gao, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shaanxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.