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REVIEW article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1488715
This article is part of the Research Topic Exploring the Complex Interplay between Obesity, Mitochondria and Metabolic Health View all 6 articles

Effect of bariatric surgery on mitochondrial remodeling in human skeletal muscle: a narrative review

Provisionally accepted
Xiaochuan Ge Xiaochuan Ge 1,2Zhe Wang Zhe Wang 3*Yafeng Song Yafeng Song 1,2*Hua Meng Hua Meng 3*
  • 1 Department of Exercise Physiology, Beijing Sport University, Beijing, China
  • 2 Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China
  • 3 Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    In the context of obesity epidemic as a major global public health challenge, bariatric surgery stands out for its significant and long-lasting effectiveness in addressing severe obesity and its associated comorbidities. Skeletal muscule mitochondrial function, which is crucial for maintaining metabolic health, tends to deteriorate with obesity. This review summarized current evidence on the effects of bariatric surgery on skeletal muscle mitochondrial function, with a focus on mitochondrial content, mitochondrial dynamics, mitochondrial respiration and mitochondrial markers in glucolipid metabolism. In conclusion, bariatric surgery impacts skeletal muscle through pathways related to mitochondrial function and induces mitochondrial remodeling in skeletal muscle in various aspects.Future studies should focus on standardized methodologies, larger sample sizes, and better control of confounding factors to further clarify the role of mitochondrial remodeling in the therapeutic benefits of bariatric surgery.

    Keywords: Obesity, type 2 diabetes, Weight-loss surgery, Skeletal muscle mitochondria, metabolism Roux-en-Y gastric bypass ( Deleted:

    Received: 30 Aug 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Ge, Wang, Song and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhe Wang, Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
    Yafeng Song, Department of Exercise Physiology, Beijing Sport University, Beijing, China
    Hua Meng, Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.