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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1488309

Association between visceral adipose surrogates and infertility among reproductive-aged females: A crosssectional study

Provisionally accepted
Dongli Guo Dongli Guo *Ruiya Wang Ruiya Wang
  • Zhumadian Central Hospital, Zhumadian, China

The final, formatted version of the article will be published soon.

    Background: Visceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.This study employed a cross-sectional design and analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2012(NHANES, -2016)). Weighted logistic regression models were utilized to examine the association between VAT surrogates and infertility. Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the diagnostic efficacy of these surrogates for infertility.: Individuals experiencing infertility exhibited markedly elevated levels of the Chinese Visceral Adiposity Index (CVAI) (108.30 vs. 69.86, P<0.001) and Visceral Adiposity Index (VAI) (1.68 vs. 1.35, P<0.001). When considered as a continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, P<0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, P=0.259), demonstrated a significant association with the risk of female infertility. Consistent findings were also evident after dividing participants into 4 subgroups based on CVAI quartiles. Additionally, ROC curves indicated that CVAI exhibited the most robust diagnostic value for female infertility compared to other indices. Subgroup analyses revealed a robust association between CVAI and infertility across different populations. Conclusion: Females with elevated CVAI levels faced a significantly heightened risk of infertility in the United States. CVAI holds promise as a valuable tool for stratifying the risk of infertility.

    Keywords: visceral adipose tissue, Female infertility, NHANES, biomarkers, Obesity

    Received: 29 Aug 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Guo and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dongli Guo, Zhumadian Central Hospital, Zhumadian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.