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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1488175

Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity

Provisionally accepted
Markus Engelmann Markus Engelmann 1Juliane Götze Juliane Götze 1Philipp Baumbach Philipp Baumbach 1Charles Neu Charles Neu 1Utz Settmacher Utz Settmacher 2Michael Ardelt Michael Ardelt 2Hermann Kissler Hermann Kissler 2Sina M. Coldewey Sina M. Coldewey 1*
  • 1 Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
  • 2 Department of General, Visceral and Vascular Surgery, University Hospital Jena, Jena, Thuringia, Germany

The final, formatted version of the article will be published soon.

    The prevalence of obesity is increasing at an alarming rate in industrialized countries. Obesity is a systemic disease that causes not only macroscopic alterations, but also mitochondrial dysfunction. Laparoscopic sleeve gastrectomy (LSG) poses a potential therapeutic option for patients with severe obesity. In order to ascertain the efficacy of bariatric interventions, it is important to assess not only weight loss, but also changes in body composition. Additionally, the aim of this study was to investigate the association between weight loss and cellular oxygen metabolism, a surrogate for mitochondrial function.We used bioimpedance analysis (BIA) to assess changes in weight and body composition in patients up to one year after LSG. To evaluate mitochondrial oxygen metabolism, we used the Cellular Oxygen Metabolism Monitor (COMET) to non-invasively measure the mitochondrial oxygen tension (mitoPO2), mitochondrial oxygen consumption (mitoVO2) and mitochondrial oxygen delivery (mitoDO2). We compared the values obtained in patients with obesity with those of age-and sexmatched healthy controls and investigated changes up to one year after LSG. 48 patients (46.5 years [35.5-55.3]; 38/48 female (79.2%); ) completed the study. They showed a significant weight loss and a decrease in relative fat mass after six months. We found no differences in mitochondrial oxygen metabolism between obese patients and healthy controls. MitoPO2, mitoVO2 and mitoDO2 did not change up to one year after surgery. It is noteworthy that patients who exhibited higher mitoPO2, mitoVO2, and mitoDO2 values prior to surgery demonstrated superior weight loss outcomes one year after LSG.This was the first study to investigate the non-invasively measured mitochondrial oxygen metabolism in the long-term course after bariatric surgery. Further studies in larger cohorts are needed to confirm these findings.

    Keywords: Obesity1, sleeve gastrectomy2, bioimpedance analysis3, Mitochondrial dysfunction4, mitochondrial oxygen metabolism5, COMET6

    Received: 30 Aug 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Engelmann, Götze, Baumbach, Neu, Settmacher, Ardelt, Kissler and Coldewey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sina M. Coldewey, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany

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