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REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1485876
This article is part of the Research Topic Stem Cells and Extracellular Vesicles in Bone Health, Disease and Regeneration - Volume II View all articles
Challenges in Tendon-Bone Healing: Emphasizing Inflammatory Modulation Mechanisms and Treatment
Provisionally accepted- 1 Qingdao University, Qingdao, China
- 2 Qingdao Municipal Hospital, Qingdao, Shandong Province, China
Tendons are fibrous connective tissues that transmit force from muscles to bones. Despite their ability to withstand various loads, tendons are susceptible to significant damage. The healing process of tendons and ligaments connected to bone surfaces after injury presents a clinical challenge due to the intricate structure, composition, cellular populations, and mechanics of the interface. Inflammation plays a pivotal role in tendon healing, creating an inflammatory microenvironment through cytokines and immune cells that aid in debris clearance, tendon cell proliferation, and collagen fiber formation. However, uncontrolled inflammation can lead to tissue damage, and adhesions, and impede proper tendon healing, culminating in scar tissue formation. Therefore, precise regulation of inflammation is crucial. This review offers insights into the impact of inflammation on tendon-bone healing and its underlying mechanisms. Understanding the inflammatory microenvironment, cellular interactions, and extracellular matrix dynamics is essential for promoting optimal healing of tendon-bone injuries. The roles of fibroblasts, inflammatory cytokines, chemokines, and growth factors in promoting healing, inhibiting scar formation, and facilitating tissue regeneration are discussed, highlighting the necessity of balancing the suppression of detrimental inflammatory responses with the promotion of beneficial aspects to enhance tendon healing outcomes. Additionally, the review explores the significant implications and translational potential of targeted inflammatory modulation therapies in refining strategies for tendon-bone healing treatments.
Keywords: Inflammation1, macrophage2, fibroblasts3, tendon-bone healing4, Biomaterials5
Received: 25 Aug 2024; Accepted: 11 Oct 2024.
Copyright: © 2024 Jiang, Zhao, Zhang, Bi, Zhang, Sun, Yao, Zhu, Yang, Liu, Xu, Yu and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan Jiang, Qingdao University, Qingdao, China
Po Zhang, Qingdao University, Qingdao, China
Haoyun Zhang, Qingdao University, Qingdao, China
Shenjie Sun, Qingdao Municipal Hospital, Qingdao, 266011, Shandong Province, China
Fenghua Yang, Qingdao University, Qingdao, China
Yang Liu, Qingdao University, Qingdao, China
Sicong Xu, Qingdao University, Qingdao, China
Tengbo Yu, Qingdao Municipal Hospital, Qingdao, 266011, Shandong Province, China
Xiao Xiao, Qingdao Municipal Hospital, Qingdao, 266011, Shandong Province, China
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