Skip to main content

MINI REVIEW article

Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1484524

Hyperactive Browning and Hypermetabolism: Potentially Dangerous Element in Critical Illness

Provisionally accepted
Shenglu Jiang Shenglu Jiang 1Lili Zhu Lili Zhu 2*Zhenxiong Zhao Zhenxiong Zhao 1Lu Huang Lu Huang 1*
  • 1 Taizhou Central Hospital, Taizhou, China
  • 2 Taizhou Enze Hospital, Taizhou, Zhejiang, China

The final, formatted version of the article will be published soon.

    Brown/beige adipose tissue has attracted much attention in previous studies because it can improve metabolism and combat obesity through non-shivering thermogenesis.However, recent studies have also indicated that especially in critical illness, overactivated brown adipose tissue or extensive browning of white adipose tissue may bring damage to individuals mainly by exacerbating hypermetabolism. In this review, the phenomenon of fat browning in critical illness will be discussed, along with the potential harm, possible regulatory mechanism and corresponding clinical treatment options of the induction of fat browning. The current research on fat browning in critical illness will offer more comprehensive understanding of its biological characteristics, and inspire researchers to develop new complementary treatments for the hypermetabolic state that occurs in critically ill patients.

    Keywords: brown adipose tissue, Beige adipose tissue, Critical Illness, Thermogenesis, Hypermetabolism, Metabolic disorder

    Received: 22 Aug 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Jiang, Zhu, Zhao and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lili Zhu, Taizhou Enze Hospital, Taizhou, Zhejiang, China
    Lu Huang, Taizhou Central Hospital, Taizhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.