Jie Gao
1*
Wenwen Chen
1*The final, formatted version of the article will be published soon.
SYSTEMATIC REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1481649
The characteristic expression of circulating microRNAs in osteoporosis: a systematic review and meta-analysis
Provisionally accepted- 1 Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
- 2 Department of Stomatology, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Objective: To evaluate the characteristics of the circulating microRNAs expression profile in patients with osteoporosis. Methods: A systematic literature search was performed using the databases of Web of science, PubMed, Embase, Cochrane library, CNKI, VIP and WANFANG from inception until March 1, 2024. The search strategy employed keywords encompassed "osteoporosis or bone loss or osteopenia" and "miRNA or microRNA". The NOS quality assessment scale was used to evaluate methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Total of 27 studies were included and analyzed in the meta-analysis, with 2263 participants. The results showed that miR-21-5p (WMD 0.88, 95% CI: 0.22 to 1.55), miR-125b-5p (WMD 6.63, 95% CI: 0.19 to 13.08), miR-483-5p(WMD 6.43, 95% CI: 3.26 to 9.61), miR-133a (WMD 1.43, 95% CI: 1.39 to 1.47), miR-422a (WMD 1, 95% CI: 0.28 to 1.72) and miR-214-3p (WMD 2.03, 95% CI: 0.14 to 3.92) were up-regulated significantly, and miR-497-5p (WMD -0.57, 95% CI: -0.98 to -0.17) was down-regulated significantly. Conclusion: MiR-21-5p, miR-125b-5p, miR-483-5p, miR-133a, miR-497-5p, miR-422a, and miR-214-3p might serve as potential diagnostic biomarkers of osteoporosis. In the further, integrating these miRNAs to build diagnostic model might be promising diagnosis strategy for osteoporosis.
Keywords: microRNA, Expression, diagnosis, Osteoporosis, Meta-analysis
Received: 16 Aug 2024; Accepted: 18 Nov 2024.
Copyright: © 2024 Gao, Zhang, Ding, Zhang, Zhang, Jiang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jie Gao, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Xiu-Zhen Zhang, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Jing Ding, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Houli Zhang, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Xu Zhang, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Juan Jiang, Department of Stomatology, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Wenwen Chen, Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
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