Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1477419

The atherogenic index of plasma is associated with an increased risk of diabetes in non-obese adults：a cohort study

Provisionally accepted
Zhenhua Huang Zhenhua Huang 1*Jun Cao Jun Cao 2Zhaohai Su Zhaohai Su 2*Jiangyong Yang Jiangyong Yang 2*Bilong Zhang Bilong Zhang 2*Rengui Jiang Rengui Jiang 2*Lu Weiling Lu Weiling 2Zheng Xie Zheng Xie 2*
  • 1 Shenzhen Second People's Hospital, Shenzhen, China
  • 2 Ganzhou Municipal Hospital, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to investigate the relationship between the atherogenic index of plasma (AIP) and diabetes risk in Chinese non-obese adults. This is important because the incidence of diabetes is significant in non-obese populations, and evidence regarding this association is limited.We conducted a retrospective cohort study with 82,977 Chinese non-obese adults. We used Cox proportional hazards regression to assess the relationship between baseline AIP levels and diabetes incidence. We also employed cubic spline functions and smooth curve fitting to investigate potential nonlinear relationships. Sensitivity and subgroup analyses were conducted to validate our findings.The median follow-up duration for these participants was 3.10 years, during which 1,041 subjects (1.25%) were diagnosed with diabetes. Adjusted analyses demonstrated a strong positive association between AIP and the risk of diabetes onset (HR 2.07; 95% CI: 1.63-2.63; p < 0.001). The risk of diabetes increased with higher AIP quartiles, especially between the highest (Q4) and lowest (Q1) quartiles (adjusted HR 1.55; 95% CI: 1.27-1.89). We also identified a nonlinear relationship between AIP and diabetes risk. Sensitivity and subgroup analyses confirmed these findings.Furthermore, E-value analysis indicated that the results were robust against unmeasured confounding variables.Our findings highlight a positive, nonlinear association between AIP and diabetes risk in Chinese non-obese adults. Lowering triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C) levels may help reduce this risk.

    Keywords: Atherogenic index of plasma, diabetes, Non-obese, Chinese adults, non-linear

    Received: 07 Aug 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Huang, Cao, Su, Yang, Zhang, Jiang, Weiling and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhenhua Huang, Shenzhen Second People's Hospital, Shenzhen, China
    Zhaohai Su, Ganzhou Municipal Hospital, Ganzhou, 341000, Jiangxi Province, China
    Jiangyong Yang, Ganzhou Municipal Hospital, Ganzhou, 341000, Jiangxi Province, China
    Bilong Zhang, Ganzhou Municipal Hospital, Ganzhou, 341000, Jiangxi Province, China
    Rengui Jiang, Ganzhou Municipal Hospital, Ganzhou, 341000, Jiangxi Province, China
    Zheng Xie, Ganzhou Municipal Hospital, Ganzhou, 341000, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.