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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1475933

Higher remnant cholesterol increases the risk of coronary heart disease and diabetes in postmenopausal women

Provisionally accepted
Yan Zhang Yan Zhang 1Kexin Song Kexin Song 2Shuli Bi Shuli Bi 3Mingyang Li Mingyang Li 1Zhuhua Yao Zhuhua Yao 4*
  • 1 Tianjin Medical University, Tianjin, China
  • 2 Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 3 Nankai University, Tianjin, China
  • 4 The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, China

The final, formatted version of the article will be published soon.

    Background: Postmenopausal women represent the demographic increasingly susceptible to cardiovascular and metabolic diseases. Elevated levels of remnant cholesterol (RC) have been implicated in atherosclerosis and insulin resistance.Methods: This study aimed to investigate the relationship between RC and the prevalence of coronary heart disease (CHD), diabetes, and CHD combined with diabetes in a nationally representative sample of US postmenopausal women using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Multivariate logistic regression models were employed to evaluate the association between RC and the outcomes of interest. Nonlinear relationships were examined using restricted cubic splines (RCS), and subgroup analyses and interaction tests were conducted.Results: A total of 1611 participants were included in the final analysis. Higher RC levels were significantly associated with increased risks of CHD [OR=1.67, 95%CI (1.02, 2.74)], diabetes [OR=1.77, 95%CI (1.22, 2.58)], and CHD combined with diabetes [OR=2. 28, 95%CI (1.17, 4.42)] (all P<0.05). Compared to the lowest RC quartile (Q1), the highest quartile (Q4) demonstrated elevated incidences of CHD [OR=1.76, 95%CI (1.04, 2.98)], diabetes [OR=1.81, 95%CI (1.30, 2.53)], and CHD combined with diabetes [OR=3. 08, 95%CI (1.29, 7.37)] (all P<0.05). RCS curves indicated a nearly linear relationship between RC and the risks of CHD, diabetes, and CHD combined with diabetes.Our study reveals a significant positive correlation between RC levels and the prevalence of CHD, diabetes, and CHD combined with diabetes among postmenopausal women. Understanding these associations could potentially inform targeted prevention and management strategies tailored to this vulnerable population.

    Keywords: Remnant cholesterol, coronary heart disease, diabetes, postmenopausal women, risk factor

    Received: 04 Aug 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Zhang, Song, Bi, Li and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhuhua Yao, The Institute of Translational Medicine, Tianjin Union Medical Center of Nankai University, Tianjin, 300071, China

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