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SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1475531
This article is part of the Research Topic New insights: Developments in laboratory testing for the diagnosis and monitoring of endocrine related disorders and metabolic disease View all 8 articles

MMP-9 as a clinical marker for endometriosis: A meta-analysis and bioinformatics analysis

Provisionally accepted
Qiumei Huang Qiumei Huang 1,2Yanlun Song Yanlun Song 1,2Xiaocan Lei Xiaocan Lei 3Hua Huang Hua Huang 4*Weihua Nong Weihua Nong 1,2*
  • 1 Youjiang Medical University for Nationalities, Baise, China
  • 2 Department of Obstetrics and Gynecology, Affiliated Hospital of Youjiang Medical University for Nationalities, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases, baise, China
  • 3 Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China,, Hengyang, China
  • 4 Reproductive Hospital of Guangxi Zhuang Autonomous Region,No.3, Longyuan Road, Qingxiu District, Nanning City, Guangxi,, nanning, China

The final, formatted version of the article will be published soon.

    Aim: This study systematically evaluated the potential efficacy of serum matrix metalloproteinase-9 (MMP-9) concentration as a diagnostic marker for endometriosis through meta-analysis. Early and accurate diagnosis of endometriosis, a common gynecological disease, is crucial for improving patient prognosis. Hence, this study aimed to comprehensively analyze the data from multiple studies to assess the diagnostic value of serum MMP-9 concentration for endometriosis. Methods: Articles investigating the association between MMP-9 and endometriosis, published from the inception of the databases until February 2024, were systematically retrieved from multiple databases, including PubMed, Embase, Cochrane, Web of Science, Scopus, and CNKI. Download and analyze the GSE7305, GSE23339, and GSE51981 datasets. Statistical analyses of all eligible studies were conducted using RevMan 5.4, Stata 11.0, and R software version 4.3.3.Results: Fifteen studies fully met the inclusion criteria for the meta-analysis. The concentration of MMP-9 in the blood of patients with endometriosis was significantly higher compared to that of the control group (p < 0.0001). Subgroup analysis based on different stages of endometriosis revealed a trend towards significantly higher serum MMP-9 concentrations in patients, whether in stages I-II or III-IV.Bioinformatics analysis revealed differences in the expression of MMP-9 in endometrial tissue between EMT patients and healthy controls in the GSE7305 and GSE23339 datasets. Additionally, in the GSE51981 dataset, we found significant differences between the normal group and both mild and severe cases of endometriosis.Both the current meta-analysis and bioinformatics analysis indicate differences in MMP-9 concentration levels between endometriosis patients and healthy individuals, with potentially elevated MMP-9 concentrations in serum samples from patients with endometriosis.

    Keywords: Matrix Metalloproteinase 9, Endometriosis, Systematic review, Meta-analysis, Bioinformatics analysis

    Received: 04 Aug 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Huang, Song, Lei, Huang and Nong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hua Huang, Reproductive Hospital of Guangxi Zhuang Autonomous Region,No.3, Longyuan Road, Qingxiu District, Nanning City, Guangxi,, nanning, China
    Weihua Nong, Youjiang Medical University for Nationalities, Baise, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.