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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1474201
Evaluating the impact of visceral fat on the outcomes of frozen embryo transfer via bioelectrical impedance analysis
Provisionally accepted- 1 Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
- 2 Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China
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The increasing prevalence of obesity underscores the need to explore its impact on assisted reproductive technology (ART) outcomes. This study aims to evaluate the association between visceral fat area (VFA), measured by bioelectrical impedance analysis (BIA), and pregnancy outcomes following frozen embryo transfer (FET).In this retrospective clinical study, the data of 1,510 patients who underwent FET between April 2022 and April 2023 were analyzed. The VFA was measured by BIA, and patients were categorized into low and high VFA groups based on a threshold of 65 cm². Pregnancy outcomes were compared between the two groups. Univariable and multivariate logistic regression analyses, along with restricted cubic spline (RCS) modeling, were used to adjust for age, body mass index (BMI), and basal estradiol (E2) levels to determine the relationship between VFA and FET outcomes.Results: There were significant differences in baseline characteristics and outcomes between the two groups. The high VFA group was characterized by older age and a lower basal estradiol (E2) level. The biochemical pregnancy rate, implantation rate, clinical pregnancy rate (CPR), and live birth rate (LBR) were significantly lower in the high VFA group. Logistic regression revealed a significant negative correlation between the high VFA group and both CPR and LBR. The RCS model demonstrated that the VFA was nonlinearly correlated with CPR and LBR. Subgroup analysis showed that among individuals under 35 years of age or with a BMI < 24, high VFA was significantly associated with poorer CPR and LBR.Conclusions: High VFA is associated with poorer pregnancy outcomes after FET in female patients with infertility, with both CPR and LBR decreasing as VFA increases.Clinicians should consider VFA as an important reference for targeted fat management interventions to optimize reproductive success, especially when VFA exceeds 65 cm².
Keywords: Visceral fat area (VFA), Bioelectrical Impedance Analysis (BIA), Frozen embryo transfer (FET), Clinical pregnancy rate (CPR), Live birth rate (LBR)
Received: 01 Aug 2024; Accepted: 18 Dec 2024.
Copyright: © 2024 Ni, Wei, Xie, Wang, Yu, Jiang, Yang and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Danyu Ni, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Yi Wei, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Xinyu Wang, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Kaidi Yu, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Wei Jiang, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Ye Yang, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
Xiufeng Ling, Department of Reproductive Medicine, Nanjing Women and Children’s HealthCare Hospital, Nanjing, Liaoning Province, China
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