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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1471548
This article is part of the Research Topic Cardiometabolic diseases in postmenopausal women View all 4 articles

Association between serum Klotho levels and estimated pulse wave velocity in postmenopausal women: a cross-sectional study of NHANES 2007-2016

Provisionally accepted
Baiqiang Wang Baiqiang Wang 1Wenqu Xu Wenqu Xu 1Zeyuan Mei Zeyuan Mei 1Wei Yang Wei Yang 2Xiao Meng Xiao Meng 1*Guipeng An Guipeng An 1*
  • 1 Qilu Hospital, Shandong University, Jinan, China
  • 2 People’s Hospital of Rizhao, Rizhao, China

The final, formatted version of the article will be published soon.

    Backgr ound: Postmenopausal women are at an increased risk of arterial stiffness, which can be assessed using estimated pulse wave velocity (ePWV). This study aimed to investigate the relationship between serum klotho levels and ePWV in postmenopausal women.: This cross-sectional study used data from postmenopausal women who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016. Participants were divided into two groups based on the presence of hypertension. Weighted multivariate linear regression was used to analyze the relationship between serum Klotho levels and ePWV in each group.Restricted cubic spline models with multivariable adjustments were employed to examine nonlinear associations within each group.Results: Our analysis included 4,468 postmenopausal women from the NHANES database, with 1,671 in the non-hypertensive group and 2,797 in the hypertensive group. In all regression models, serum Klotho (ln-transformed) levels were significantly and independently negatively correlated with ePWV in the non-hypertensive group. After fully adjusting for confounders, a 1-unit increase in ln(Klotho) was associated with a 0.13 m/s decrease in ePWV (β = -0.13, 95% CI -0.23 to -0.03; p = 0.008). Additionally, in the fully adjusted model, participants in the highest quartile of ln(Klotho) had an ePWV value 0.14 m/s lower than those in the lowest quartile (p for trend = 0.017; 95% CI -0.23 to -0.05; p = 0.002). This negative correlation was consistent across subgroups and was particularly significant among women aged < 60 years, nonsmokers, and non-Hispanic Black women. However, no association was observed between serum Klotho levels and ePWV in the hypertensive group.Klotho level and ePWV in postmenopausal women. Increased serum Klotho levels may reduce arterial stiffness in postmenopausal women.Further studies are required to confirm these findings.

    Keywords: serum Klotho, estimated pulse wave velocity, postmenopausal women, Hypertension, arterial stiffness

    Received: 27 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Wang, Xu, Mei, Yang, Meng and An. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao Meng, Qilu Hospital, Shandong University, Jinan, China
    Guipeng An, Qilu Hospital, Shandong University, Jinan, China

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