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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1469055

The associations of triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study

Provisionally accepted
Junpeng Xu Junpeng Xu Xiong-Qiang Peng Xiong-Qiang Peng Li-Heng Guo Li-Heng Guo Xu-Jie Zhao Xu-Jie Zhao Mao-Sheng Chen Mao-Sheng Chen Xiaoyi Mai Xiaoyi Mai Jia-Wei Tan Jia-Wei Tan Quanfu Chen Quanfu Chen Rui-Xiang Zeng Rui-Xiang Zeng *Minzhou Zhang Minzhou Zhang *
  • Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    The triglyceride-glucose (TyG) index, a reliable surrogate biomarker of insulin resistance (IR), is highlighted recently as related to cardiac disorders. However, the associations of TyG index and its combination with blood pressure (BP) on cardiovascular and all-cause mortality in hypertension remain unclear. In this study, we included 9,635 hypertension patients from the National Health and Nutrition Examination Survey 1999-2018. During a median follow-up of 8.00 years, a total number of 853 and 2,489 in cardiovascular and all-cause deaths occurred. After fully adjustments, individual TyG index was positively associated with cardiovascular and all-cause mortality with J-shaped dose-response relationships. The lowest risk thresholds of TyG index for cardiovascular and all-cause mortality were 9.5551 and 9.3405, respectively. In joint analyses, the highest risks of cardiovascular and all-cause mortality were observed among those with elevated levels of both BP and IR [1.64 (1.18, 2.28), P = 0.0031; 1.39 (1.14, 1.70), P = 0.0011; respectively]. In sensitivity and subgroup analyses, the results were generally robust. Our data appeal a hypothesis that future treatments for hypertension may require a combination of BP controlled and IR improvement.

    Keywords: Triglyceride-glucose index, Insulin Resistance, Blood Pressure, Mortality, Joint analyses

    Received: 23 Jul 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Xu, Peng, Guo, Zhao, Chen, Mai, Tan, Chen, Zeng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rui-Xiang Zeng, Guangzhou University of Chinese Medicine, Guangzhou, China
    Minzhou Zhang, Guangzhou University of Chinese Medicine, Guangzhou, China

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