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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1468824

Exploring Lipodystrophy Gene Expression in Adipocytes: Unveiling Insights into the Pathogenesis of Insulin Resistance, Type 2 Diabetes, and Clustering Diseases (Metabolic Syndrome) in Asian Indians

Provisionally accepted
Aditya Saxena Aditya Saxena 1Pradeep Tiwari Pradeep Tiwari 2Shalu Gupta Shalu Gupta 2Rajendra Mandia Rajendra Mandia 2Ramesh C. Banshiwal Ramesh C. Banshiwal 2Ravinder K. Lamoria Ravinder K. Lamoria 2Ranjit Mohan Anjana Ranjit Mohan Anjana 3Venkatesan Radha Venkatesan Radha 3Viswanathan Mohan Viswanathan Mohan 3Sandeep K. Mathur Sandeep K. Mathur 2*
  • 1 Department of Computer Engineering & Applications, GLA University, Mathura, Uttar Pradesh, India
  • 2 Sawai ManSingh Medical College, Jaipur, India
  • 3 Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India

The final, formatted version of the article will be published soon.

    Background: Studying the molecular mechanisms of lipodystrophy can provide valuable insights into the pathophysiology of insulin resistance (IR), T2D, and other clustering diseases (Metabolic syndrome, MetS) and its underlying adipocentric disease (MetS disease).Methods: A high-confidence lipodystrophy gene panel comprising fifty genes was created and their expressions were measured in visceral and subcutaneous (both peripheral and abdominal) adipose depot of MetS and non-MetS individuals at a tertiary care medical facility.Results: Most lipodystrophy genes showed significant downregulation in MetS individuals compared to non-MetS in both subcutaneous and visceral depots. In the abdominal compartment all the genes showed relatively higher expression in visceral depot as compared to their subcutaneous counterpart and this difference narrowed with increasing severity of MetS. Their expression level shows an inverse correlation with T2D, MetS, and HOMA-IR and with other T2D-related intermediate traits. Results also demonstrated that individualization of MetS patients could be done based on adipose tissue expression of just twelve genes.Adipose tissue expression of lipodystrophy genes show an association with MetS and its intermediate phenotypic traits. Mutations of these genes are known to cause congenital lipodystrophy syndromes, whereas, their altered expression in adipose tissue contributes to pathogenesis of IR, T2D and MetS .

    Keywords: Lipodystrophy, type 2 diabetes, Asian Indians, Central obesity, Insulin Resistance, Metabolic syndrome MetS, qPCR, Adipose Tissue

    Received: 22 Jul 2024; Accepted: 16 Sep 2024.

    Copyright: © 2024 Saxena, Tiwari, Gupta, Mandia, Banshiwal, Lamoria, Anjana, Radha, Mohan and Mathur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sandeep K. Mathur, Sawai ManSingh Medical College, Jaipur, India

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