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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1468820
This article is part of the Research Topic Advances in Diabetes and Hypertension Research View all 3 articles

Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes

Provisionally accepted
Xingxi Lin Xingxi Lin 1,2Luhan Zhou Luhan Zhou 1,2Shuting Si Shuting Si 3Haoyue Cheng Haoyue Cheng 1,2Xialidan Alifu Xialidan Alifu 1,2Yiwen Qiu Yiwen Qiu 1,2Yan Zhuang Yan Zhuang 1,2Ye Huang Ye Huang 1,2Libi Zhang Libi Zhang 1,2Diliyaer Ainiwan Diliyaer Ainiwan 1,2Hui Liu Hui Liu 4Yunxian Yu Yunxian Yu 1,2*
  • 1 Department of Anesthesiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  • 2 Department of Epidemiology and Health Statistics, School of Public Health, School of Medicine, Hangzhou, China
  • 3 Yiwu Maternity and Children Health Care Hospital, Jinhua, Zhejiang Province, China
  • 4 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

The final, formatted version of the article will be published soon.

    Backgrounds Many pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.The data was from the Zhoushan Maternal and Child Health Hospital electronic medical recorder system (EMRS) between 2015 and 2022. Multivariate linear regression model was used to analyze the association of GDM, HDP, and comorbidity with birth weight and gestational age, respectively. Multiple logistic regression model was used to analyze the association of GDM, HDP, and comorbidity with adverse birth outcomes.Results 13645 pregnant women were included. GDM+HDP was significantly associated with a higher risk of composite adverse neonatal outcomes (OR=1.82, 95%CI: 1.02-3.04), including preterm birth, placenta previa, and/or neonatal jaundice, a higher risk of small for gestational age (SGA) (OR=2.2, 95% CI: 1.24 3.92) and large for gestational age (LGA) (OR=2.33, 95% CI: 1.64 3.31) compared with the normal group. Further analysis showed that HDP diagnosed in the 21-27 th week comorbid with GDM had the lowest gestational age at delivery (  = -1.57, P=0.0002) and birth weight (= -189.57, P=0.0138). Moreover, combined hyperglycemia (CH) comorbid with HDP had the strongest association with reduced gestational age (= -0.83, P=0.0021).Pregnant women suffering from both GDM and HDP had a higher risk of adverse neonatal outcomes; hence, the prevent and treatment of GDM and HDP, especially their comorbidity, are very important for pregnant women.

    Keywords: gestational diabetes mellitus, Hypertension disorders, Pregnancy, Adverse neonatal outcomes, Comorbidity

    Received: 22 Jul 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Lin, Zhou, Si, Cheng, Alifu, Qiu, Zhuang, Huang, Zhang, Ainiwan, Liu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yunxian Yu, Department of Anesthesiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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