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REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1465975
This article is part of the Research Topic Diabetic Wound: Multifaceted Mechanisms and Future of Diabetic Wound Healing, Volume II View all 5 articles
The Emerging Modulators of Non-Coding RNAs In Diabetic Wound Healing
Provisionally accepted- 1 Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hebei Province, China
- 2 Department of Dermatology and Venereology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- 3 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
- 4 Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
- 5 Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
- 6 Renmin Hospital of Wuhan University, Wuhan, China
Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensively examines the roles of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating key phases of the wound healing process: inflammation, angiogenesis, re-epithelialization, and tissue remodeling. Through a deep review of current literature, we discuss recent discoveries of ncRNAs that have been shown to either promote or impair the wound healing process in diabetic wound healing, which were not covered in earlier reviews. This review highlights the specific mechanisms by which these ncRNAs impact cellular behaviors and pathways critical to each healing stage. Our findings indicate that understanding these recently identified ncRNAs provides new insights into their potential roles in diabetic wound healing, thereby contributing valuable knowledge for future research directions in this field.
Keywords: diabetic wound, Diabetic foot ulcer, non-coding RNA, microRNA, long non-coding RNA, circular RNA
Received: 17 Jul 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Aghayants, Zhu, Yu, Tao, Li, Zhou, Zhou and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinjin Zhu, Department of Dermatology and Venereology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
Rui Tao, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
Sicheng Li, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
Shengzhi Zhou, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
Yunhua Zhou, Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, Hebei Province, China
Zhanyong Zhu, Renmin Hospital of Wuhan University, Wuhan, China
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