Skip to main content

REVIEW article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1465975
This article is part of the Research Topic Diabetic Wound: Multifaceted Mechanisms and Future of Diabetic Wound Healing, Volume II View all 5 articles

The Emerging Modulators of Non-Coding RNAs In Diabetic Wound Healing

Provisionally accepted
Sis Aghayants Sis Aghayants 1Jinjin Zhu Jinjin Zhu 2*Jing Yu Jing Yu 3Rui Tao Rui Tao 4*Sicheng Li Sicheng Li 4*Shengzhi Zhou Shengzhi Zhou 4*Yunhua Zhou Yunhua Zhou 5*Zhanyong Zhu Zhanyong Zhu 4,6*
  • 1 Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hebei Province, China
  • 2 Department of Dermatology and Venereology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 3 Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
  • 4 Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
  • 5 Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
  • 6 Renmin Hospital of Wuhan University, Wuhan, China

The final, formatted version of the article will be published soon.

    Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensively examines the roles of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating key phases of the wound healing process: inflammation, angiogenesis, re-epithelialization, and tissue remodeling. Through a deep review of current literature, we discuss recent discoveries of ncRNAs that have been shown to either promote or impair the wound healing process in diabetic wound healing, which were not covered in earlier reviews. This review highlights the specific mechanisms by which these ncRNAs impact cellular behaviors and pathways critical to each healing stage. Our findings indicate that understanding these recently identified ncRNAs provides new insights into their potential roles in diabetic wound healing, thereby contributing valuable knowledge for future research directions in this field.

    Keywords: diabetic wound, Diabetic foot ulcer, non-coding RNA, microRNA, long non-coding RNA, circular RNA

    Received: 17 Jul 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Aghayants, Zhu, Yu, Tao, Li, Zhou, Zhou and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jinjin Zhu, Department of Dermatology and Venereology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Rui Tao, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
    Sicheng Li, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
    Shengzhi Zhou, Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China., Wuhan, Hebei Province, China
    Yunhua Zhou, Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430077, Hebei Province, China
    Zhanyong Zhu, Renmin Hospital of Wuhan University, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.