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SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1464959
This article is part of the Research Topic Weighing the Impact of Being Overweight on Female Reproductive Function and Fertility View all 7 articles

Different supplements improve insulin resistance, hormonal functions, and oxidative stress on overweight and obese women with polycystic ovary syndrome: A systematic review and meta-analysis

Provisionally accepted
Xiaoyan Ren Xiaoyan Ren 1,2*Wenjuan Wu Wenjuan Wu 2Qiufan Li Qiufan Li 1Wen Li Wen Li 1Xujuan Wang Xujuan Wang 1Gang Wang Gang Wang 2
  • 1 Chengdu Medical College, Chengdu, China
  • 2 the Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, China

The final, formatted version of the article will be published soon.

    Objectives: To investigate various supplements that improve insulin resistance, hormonal status, and oxidative stress in overweight or obese women with PCOS. Methods: 25 RCTs evaluated the efficacy of various supplements in improving IR, hormonal status, and oxidative stress among overweight or obese women diagnosed with PCOS. Data extraction and analysis were carried out to determine the quality of the study's methodological design and the potential for bias. Results: A total of 25 RCTs were carried out, and 1636 women were enrolled. The SMD were as follows: For FPG, it was -0.34 (95% CI, -0.49 to -0.19, p = 0.123, I 2 = 30.8%); for insulin, it was -0.67 (95% CI, -0.83 to -0.52, p = 0.208, I 2 = 24%); for FI, it was -0.26 (95% CI, -0.52 to -0.00, p = 0.269, I 2 = 21.9%); for HOMA-IR, it was -0.59 (95% CI, -0.73 to -0.45, p = 0.015, I 2 = 48.7%); for HOMA-B, it was -0.51 (95% CI, -0.75 to -0.27, p = 0.547, I 2 = 0%); for QUICKI, it was 0.94 (95% CI, 0.76 to -1.12, p = 0.191, I 2 = 27.5%); for total testosterone, it was -0.61 (95% CI, -1.14 to -0.09, p = 0.00, I 2 = 78.5%); for testosterone, it was -0.38 (95% CI, -0.86 to 0.10, p = 0.03, I 2 = 71.5%); for FSH, it was 0.16 (95% CI, -0.08 to 0.40, p = 0.470, I 2 = 0%); for LH, it was -0.56 (95% CI, -1.32 to 0.20, p = 0.000, I 2 = 91.1%); for SHBG, it was 0.35 (95% CI, 0.02 to 0.69, p = 0.000, I 2 = 78%); for DHEAS, it was -0.27 (95% CI, -0.76 to 0.21, p = 0.001, I 2 = 78.7%); for TAC, it was 0.87 (95% CI, 0.45 to 1.30, p = 0.004, I 2 = 71.3%); for MDA, it was -0.57 (95% CI, -0.79 to -0.36, p = 0.992, I 2 = 0.0%).Conclusion: In comparison with a placebo, supplements have a favorable effect on IR, hormonal functions, and oxidative stress in PCOS.

    Keywords: Polycystic Ovary Syndrome, Overweight, Supplements, Insulin Resistance, hyperandrogenemian

    Received: 15 Jul 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Ren, Wu, Li, Li, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoyan Ren, Chengdu Medical College, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.