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REVIEW article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1464561
This article is part of the Research Topic Infertility and Endometriosis View all 22 articles

The role of immunity in insulin resistance in patients with polycystic ovary syndrome

Provisionally accepted
Qi Xuan Zhang Qi Xuan Zhang 1Zhe Yang Zhe Yang 1Xiangyang Ou Xiangyang Ou 1Mengying Zhang Mengying Zhang 1Xiangyu Qin Xiangyu Qin 2Gengxiang Wu Gengxiang Wu 1*
  • 1 Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, China
  • 2 Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Polycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related to adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While the precise pathogenesis of PCOS remains unclear, it is now recognized that genetic, endocrine, and metabolic dysregulations all contribute significantly to its onset. The immunopathogenesis of PCOS has not been extensively explored, but there is growing speculation that immune system abnormalities may play a pivotal role. This chronic inflammatory state is exacerbated by factors such as obesity and hyperinsulinemia. Therefore, this review aims to elucidate the interplay between IR in PCOS patients, the controlled immune response orchestrated by immune cells and immunomodulatory molecules, and their interactions with adipocytes, hyperandrogenemia, chronic inflammation, and metabolic homeostasis.

    Keywords: Polycystic ovary syndrome1, insulin resistance2, Immune molecules3, immune cells4, Endocrine disorder5

    Received: 14 Jul 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Zhang, Yang, Ou, Zhang, Qin and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gengxiang Wu, Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.