AUTHOR=Wang Yuanyuan , Zou Jiayun , Zhou Hua 

TITLE=N6-methyladenine RNA methylation epigenetic modification and diabetic microvascular complications

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1462146

DOI=10.3389/fendo.2024.1462146

ISSN=1664-2392

ABSTRACT=<p>N6-methyladensine (m<sup>6</sup>A) has been identified as the best-characterized and the most abundant mRNA modification in eukaryotes. It can be dynamically regulated, removed, and recognized by its specific cellular components (respectively called “writers,” “erasers,” “readers”) and have become a hot research field in a variety of biological processes and diseases. Currently, the underlying molecular mechanisms of m<sup>6</sup>A epigenetic modification in diabetes mellitus (DM) and diabetic microvascular complications have not been extensively clarified. In this review, we focus on the effects and possible mechanisms of m<sup>6</sup>A as possible potential biomarkers and therapeutic targets in the treatment of DM and diabetic microvascular complications.</p>