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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1460652
This article is part of the Research Topic Bile Acids in Obesity-Related Diseases View all articles

Mendelian randomization based on immune cells in diabetic nephropathy

Provisionally accepted
Ye Zhou Ye Zhou Hengyan Zhang Hengyan Zhang *Heguo Yan Heguo Yan *Changxing Huang Changxing Huang *Yangwen Liu Yangwen Liu *
  • The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, China

The final, formatted version of the article will be published soon.

    Background: DKD, a leading cause of chronic kidney and end-stage renal disease, lacks robust immunological research. Recent GWAS utilizing SNPs and CNVs has shed light on immune mechanisms of kidney diseases. However, DKD's immunological basis remains elusive. Our goal is to unravel cause-effect relationships between immune cells and DKD using Mendelian randomisation.We analyzed FinnGen data (1032 DKD cases, 451,248 controls) with 731 immunocyte GWAS summaries (MP=32, MFI=389, AC=118, RC=192). We employed forward and reverse Mendelian randomization to explore causal links between immune cell traits and DKD. Sensitivity analysis ensured robustness, heterogeneity checks, and FDR correction minimized false positives.Results: Our study explored the causal link between diabetic nephropathy (DKD) and immunophenotypes using two-sample Mendelian Randomization (MR) with IVW.Nine immunophenotypes were significantly associated with DKD at p<0.05 after FDR correction. Elevated CD24, CD3 in Treg subsets, CD39+ CD4+, and CD33-HLA DR-AC correlated positively with DKD risk, while CD27 in B cells and SSC-A in CD4+ inversely correlated. Notably, while none showed significant protection, further research on immune cells' role in DKD may provide valuable insights.The results of this study show that the immune cells are closely related to DKD, which may be helpful in the future clinical study.

    Keywords: mendelian randomization study1, diabetic nephropathy2, Causal inference3, immunization4, sensitivity analysis5

    Received: 06 Jul 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Zhou, Zhang, Yan, Huang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hengyan Zhang, The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, China
    Heguo Yan, The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, China
    Changxing Huang, The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, China
    Yangwen Liu, The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.