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REVIEW article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1458848

Directly Targeting PRDM16 in Thermogenic Adipose Tissue to Treat Obesity and its Related Metabolic Diseases

Provisionally accepted
Liufeng Mao Liufeng Mao 1Jinli Lu Jinli Lu 1Yunliang Hou Yunliang Hou 1Tao Nie Tao Nie 2*
  • 1 Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China
  • 2 Hubei University of Arts and Science, Xiangyang, China

The final, formatted version of the article will be published soon.

    Obesity is increasing globally and is closely associated with a range of metabolic disorders, including metabolic associated fatty liver disease, diabetes, and cardiovascular diseases. An effective strategy to combat obesity involves stimulating brown and beige adipocyte thermogenesis, which significantly enhances energy expenditure. Recent research has underscored the vital role of PRDM16 in the development and functionality of thermogenic adipocytes. Consequently, PRDM16 has been identified as a potential therapeutic target for obesity and its related metabolic disorders. This review comprehensively examines various studies that focus on combating obesity by directly targeting PRDM16 in adipose tissue.

    Keywords: Obesity, brown adipocyte, Beige adipocyte, PRDM16, UCP1

    Received: 03 Jul 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Mao, Lu, Hou and Nie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Tao Nie, Hubei University of Arts and Science, Xiangyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.