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REVIEW article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1457985

The role of p53 in male infertility

Provisionally accepted
Jing Li Jing Li 1Xia Huang Xia Huang 2Lei Luo Lei Luo 3Jialin Sun Jialin Sun 1Qie Guo Qie Guo 1Xue Yang Xue Yang 1Chuanzhou Zhang Chuanzhou Zhang 1Beibei Ni Beibei Ni 1*
  • 1 Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China
  • 2 Department of Human Resource, the Affiliated Hospital of Qingdao University, Qingdao, China
  • 3 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China

The final, formatted version of the article will be published soon.

    The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies indicate that p53 plays multiple roles in spermatogenesis, as well as in the occurrence and development of male infertility. The representative functions of p53 in spermatogenesis include the proliferation of spermatogonial stem cells (SSCs), spermatogonial differentiation, spontaneous apoptosis, and DNA damage repair. p53 is involved in various male infertility-related diseases. Innovative therapeutic strategies targeting p53 have emerged in recent years. This review focuses on the role of p53 in spermatogenesis and male infertility and analyses the possible underlying mechanism involved. All these conclusions may provide a new perspective on drug intervention targeting p53 for male infertility treatment.

    Keywords: p53, male infertility, Spermatogenesis, drug target, strategy

    Received: 04 Jul 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Li, Huang, Luo, Sun, Guo, Yang, Zhang and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Beibei Ni, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.