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REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1457985
The role of p53 in male infertility
Provisionally accepted- 1 Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China
- 2 Department of Human Resource, the Affiliated Hospital of Qingdao University, Qingdao, China
- 3 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
The tumor suppressor p53 is a transcription factor involved in a variety of crucial cellular functions, including cell cycle arrest, DNA repair and apoptosis. Still, a growing number of studies indicate that p53 plays multiple roles in spermatogenesis, as well as in the occurrence and development of male infertility. The representative functions of p53 in spermatogenesis include the proliferation of spermatogonial stem cells (SSCs), spermatogonial differentiation, spontaneous apoptosis, and DNA damage repair. p53 is involved in various male infertility-related diseases. Innovative therapeutic strategies targeting p53 have emerged in recent years. This review focuses on the role of p53 in spermatogenesis and male infertility and analyses the possible underlying mechanism involved. All these conclusions may provide a new perspective on drug intervention targeting p53 for male infertility treatment.
Keywords: p53, male infertility, Spermatogenesis, drug target, strategy
Received: 04 Jul 2024; Accepted: 27 Sep 2024.
Copyright: © 2024 Li, Huang, Luo, Sun, Guo, Yang, Zhang and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Beibei Ni, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China
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