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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1457435
This article is part of the Research Topic Benefits and Risks of Agonist Triggering Strategies View all 9 articles

Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropinreleasing hormone agonist and antagonist in vitro fertilization cycles

Provisionally accepted
Chao Chin Hsu Chao Chin Hsu 1,2*Isabel Hsu Isabel Hsu 1Sonam Dorjee Sonam Dorjee 3Yi Chun Chen Yi Chun Chen 2Tzu Ning Chen Tzu Ning Chen 2Yu Lin Chuang Yu Lin Chuang 2
  • 1 Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
  • 2 TUBE Fertility Clinic, Tainan, Taiwan, Tainan, Taiwan
  • 3 Independent researcher, Tainan, Taiwan

The final, formatted version of the article will be published soon.

    In this study, we investigated the correlation between the ovarian sensitivity index (OSI) and clinical parameters in gonadotropin-releasing hormone (GnRH) agonists and GnRH-antagonist cycles. This retrospective study included data files of IVF treatments between January 2011 and December 2020 in a single IVF unit. The primary outcome measure was the correlation between the OSI and clinical pregnancy and live birth rates. Secondary outcomes were incidence of premature ovulation and luteinizing hormone (LH) surge. A generalized linear model was employed to assess group differences while controlling for age. Correlations between the OSI and clinical parameters were analyzed using Pearson's correlation test. In total, 1,627 patient data files were reviewed, comprising 1,160 patients who received GnRH antagonists and 467 who received GnRH agonists. There was no difference in the incidence of premature ovulation and LH surge in women receiving either GnRH antagonists or agonists. A higher number of mature oocytes and good embryos were obtained in the GnRH agonist cycles. No differences were observed in clinical pregnancy and live birth rates between both groups. Regarding the correlation of the OSI with clinical parameters, serum anti-Müllerian hormone, cycle day 2 follicle-stimulating hormone, LH, and estradiol concentrations, numbers of larger follicles, fertilization rate, and the incidence of premature LH surge were positively correlated with the OSI. Whereas the body mass index, mature oocytes obtained, embryo transfer number, and dose of GnRH antagonists were negatively correlated with the OSI. In the GnRH antagonists group, an OSI of 225.75 significantly distinguished pregnancy from non-pregnancy (p < 0.001), with an AUC of 0.615, and an OSI of 208.62 significantly distinguished live births from non-live births (p < 0.001), with an AUC of 0.637. As for the GnRH agonist group, an OSI of 228 significantly distinguished live births from non-live births, (p =0.020) with an AUC of 0.569.

    Keywords: GnRH-agonist, GnRH-antagonist, ovarian sensitivity index, Controlled ovarian hyperstimulation, in vitro fertilization, Clinical pregnancy rate, live birth rate

    Received: 30 Jun 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Hsu, Hsu, Dorjee, Chen, Chen and Chuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chao Chin Hsu, Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan

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