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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1456885
This article is part of the Research Topic Effects and Mechanisms of Bariatric Surgery in Relieving Obesity and Its Complications View all 11 articles

Intestinal rearrangement of Biliopancreatic Limbs, Alimentary Limbs, and Common Limbs in Obese Type 2 Diabetic Mice After Duodenal Jejunal Bypass Surgery

Provisionally accepted
Liangping Wu Liangping Wu 1,2*Heng Li Heng Li 3,4Jipei He Jipei He 5Jie Hou Jie Hou 4Chengjun He Chengjun He 4Xiaojiang Dai Xiaojiang Dai 4Zhigao Song Zhigao Song 6Qing Liu Qing Liu 7Zixin Wang Zixin Wang 1Hongyan Huang Hongyan Huang 4Yunfa Ding Yunfa Ding 4Tengfei Qi Tengfei Qi 4Hongbin Zhang Hongbin Zhang 5,8
  • 1 Department of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhoug, China
  • 2 Guangzhou Hualiang Qingying Biotechnology Co. Ltd, Guangzhou, China
  • 3 Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
  • 4 Department of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
  • 5 Department of Basic Medical Research, General Hospital of Southern Theater Command of PLA, Guangzhou, China
  • 6 Department of Cardiovascular Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China
  • 7 Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Zhongshan, China
  • 8 School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Bariatric surgery is an effective treatment for type 2 Diabetes Mellitus (T2DM), yet the precise mechanisms underlying its effectiveness remain incompletely understood.While previous research has emphasized the role of rearrangement of the gastrointestinal anatomy, gaps persist regarding the specific impact on the gut microbiota and barriers within the biliopancreatic, alimentary, and common limbs.This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on obese T2DM mice. We performed DJB and SHAM surgery in obese T2DM mice to investigate changes in the gut microbiota and barrier across different intestinal limbs. The effects on serum metabolism and potential associations with T2DM improvement were also investigated. Following DJB surgery, there was an increased abundance of commensals across various limbs. Additionally, the surgery improved intestinal permeability and inflammation in the alimentary and common limbs, while reducing inflammation in the biliopancreatic limbs. Furthermore, DJB surgery also improved T2DM by increasing L-glutamine, short-chain fatty acids, and bile acids and decreasing branched-chain amino acids. This study underscores the role of intestinal rearrangement in reshaping gut microbiota composition and enhancing gut barrier function, thereby contributing to the amelioration of T2DM following bariatric surgery, and providing new insights for further research on bariatric surgery.

    Keywords: duodenal jejunal bypass, type 2 diabetes mellitus, Gut Microbiota, Gut barrier, Metabonomics, Bariatric Surgery

    Received: 29 Jun 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Wu, Li, He, Hou, He, Dai, Song, Liu, Wang, Huang, Ding, Qi and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Liangping Wu, Department of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhoug, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.