Skip to main content

REVIEW article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1456410

Research progress on Sertoli cell secretion during spermatogenesis

Provisionally accepted
Yao Xiao Yao Xiao Jingyi Zhang Jingyi Zhang Yanxin Guan Yanxin Guan Meijing Wang Meijing Wang Dehong Liu Dehong Liu Shengxi Xiong Shengxi Xiong Junjun Li Junjun Li Xujun Yu Xujun Yu *
  • Sichuan Provincial Key Laboratory of Traditional Chinese Medicine Regulation of Metabolic Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Sertoli cells (SCs), as the somatic cells in the testis of male mammals, play a crucial role in the close association with germ cells. The blood-testicular barrier (BTB), established by their tight junctions, provides immune protection to germ cells, leading to their characterization as "sentinel" cells. Moreover, the physiological process of testicular development and spermatogenesis in male animals is intricately tied to the secretory activities of SCs. These cells secrete a diverse array of proteins and cytokines that interact with various targets, working in concert with mechanisms in the spermatogenesis pathway and contributing to each stage, from spermatogonial cell division to the maturation of spermatozoa. Hence, the secretory products of SCs are pivotal in fostering germ cell development and directing the appropriate maturation of sperm. This study is dedicated to investigating the varied secretions of SCs, outlining their critical functions throughout distinct phases of spermatogenesis, thus elucidating the substantial influence of SC secretion on male fertility. Furthermore, it offers valuable perspectives on reproductive disorders stemming from irregular spermatogenesis in clinical contexts.

    Keywords: Spermatogenesis, Germ Cells, Sertoli Cells, Lactic Acid, AMH, Cytokines

    Received: 28 Jun 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Xiao, Zhang, Guan, Wang, Liu, Xiong, Li and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xujun Yu, Sichuan Provincial Key Laboratory of Traditional Chinese Medicine Regulation of Metabolic Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.