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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1456217
This article is part of the Research Topic New Insights into the Relationship between Endocrine Disorders and Dental Diseases View all 4 articles

The mediating role of serum 25-hydroxyvitamin D on the association between reduced sensitivity to thyroid hormones and periodontitis in Chinese euthyroid adults

Provisionally accepted
Hao Yang Hao Yang 1*Yayun Lu Yayun Lu 1*Lina Zhao Lina Zhao 2*Yufeng He Yufeng He 1*Yuecheng He Yuecheng He 3Dong Chen Dong Chen 4*
  • 1 Huadong Sanatorium, Wuxi, Liaoning Province, China
  • 2 The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China
  • 3 Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China
  • 4 Shanghai Stomatological Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Aim Thyroid dysfunction is closely associated with periodontitis. We aim to explore the association between sensitivity to thyroid hormones (THs) and periodontitis and to investigate the mediating role of serum 25-hydroxyvitamin D[25(OH)D] in this relationship in Chinese euthyroid populations. Methods This population-based retrospective study included 2,530 euthyroid participants.Central sensitivity to THs was assessed by the thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyrotrophic thyroxine resistance index (TT4RI) and thyroid-stimulating hormone index (TSHI), while FT3/FT4 was evaluated to assess peripheral sensitivity. Multivariable regression analysis and restricted cubic spline were performed to explore the association between sensitivity to THs and periodontitis. Threshold effect and subgroup analysis were also conducted.Mediation analysis was performed to estimate direct and indirect effects through 25(OH)D.Multivariable regression analysis indicated that central sensitivity to THs indices(per SD increase) were positively associated with periodontitis risk [TFQI:

    Keywords: sensitivity to thyroid hormones, Periodontitis, Euthyroid, 25(OH)D, Mediation analysis

    Received: 28 Jun 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Yang, Lu, Zhao, He, He and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hao Yang, Huadong Sanatorium, Wuxi, Liaoning Province, China
    Yayun Lu, Huadong Sanatorium, Wuxi, Liaoning Province, China
    Lina Zhao, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China
    Yufeng He, Huadong Sanatorium, Wuxi, Liaoning Province, China
    Dong Chen, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.