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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Developmental Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1453083
This article is part of the Research Topic Maternal-Fetal interface: new insight in placenta research Volume II View all 5 articles

Comparative study on pregnancy complications: PGT-A vs. IVF-ET with gender-specific outcomes

Provisionally accepted
Ling Guo Ling Guo 1Xiao Li Xiao Li 2*Yufeng Wang Yufeng Wang 1Yue Liang Yue Liang 1*Yan Li Yan Li 1Xinbo Xu Xinbo Xu 2*Hong Lv Hong Lv 1*
  • 1 Shandong University, Jinan, China
  • 2 Qilu Hospital, Shandong University, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    The safety and clinical effectiveness of preimplantation genetic testing for aneuploidy (PGT-A) in improving pregnancy outcomes for sub-fertile patients remains controversial. Potential sex-based differences in the relationship between PGT-A and pregnancy complications have not been investigated, which could guide the appropriate clinical application of PGT-A. In this secondary analysis of data from a multicenter, randomized, controlled, non-inferiority trial (NCT03118141), 940 women who achieved singleton live birth during the trial were included to estimate the between-group differences in pregnancy complications following PGT-A versus conventional in vitro fertilization (IVF) vary with fetal sex. Logistic regression analysis was used to adjust for possible confounders, and subgroup analysis was also performed. Among male fetuses, the risk of maternal preeclampsia was significantly lower after PGT-A compared to conventional IVF treatment (3.37% vs. 7.88%; adjusted OR, 0.40; 95% CI, 0.17-0.92; P = 0.032). However, this protective effect was not observed in pregnancies with female fetuses (3.63% vs. 3.38%; adjusted OR, 1.04; 95% CI, 0.36-3.00; P = 0.937). In addition, no significant sex-dependent differences in the risks of other pregnancy complications or neonatal outcomes were detected between PGT-A and conventional IVF groups (P > 0.05). In summary, PGT-A was associated with a decreased risk of maternal preeclampsia in singleton pregnancies with PGT-A reduces the risk of preeclampsia male fetuses, highlighting its potential utility in preeclampsia prevention in addition to spontaneous abortion rate reduction.

    Keywords: preimplantation genetic testing for aneuploidy, in vitro fertilization and embryo transfer, singleton pregnancy, Fetal sex, Preeclampsia

    Received: 22 Jun 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Guo, Li, Wang, Liang, Li, Xu and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao Li, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Yue Liang, Shandong University, Jinan, China
    Xinbo Xu, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Hong Lv, Shandong University, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.