AUTHOR=Kim Shin-Hee , Kim Sung Eun , Chun Yoon Hong 

TITLE=The association of plasma asprosin with anthropometric and metabolic parameters in Korean children and adolescents

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1452277

DOI=10.3389/fendo.2024.1452277

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>This study aimed to determine the correlation of plasma asprosin with anthropometric and metabolic parameters in Korean children and adolescents.</p></sec><sec><title>Methods</title><p>This single-center study included 109 Korean children and adolescents: 62 (56.9%) obese participants with a body mass index (BMI) ≥95th percentile and 47 (43.1%) healthy controls with BMI between the 15th and 85th percentile. Metabolic parameters were measured, including fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and glucose (TyG) index, and lipid profiles.</p></sec><sec><title>Results</title><p>Plasma asprosin levels were higher in the obese group than in the control group (mean 87.0 vs. 69.3 ng/mL; <italic>p</italic> = 0.001) and in the IR group than in the non-IR group (mean 98.6 vs. 70.2 ng/mL; <italic>p</italic> &lt; 0.001). Plasma asprosin levels were not associated with sex or pubertal stage. Plasma asprosin levels were positively correlated with BMI SDS (<italic>r</italic> = 0.34; <italic>p</italic> = 0.002), glycated hemoglobin (HbA1c) (<italic>r</italic> = 0.25; <italic>p</italic> = 0.02), glucose (<italic>r</italic> = 0.33; <italic>p</italic> = 0.002), insulin (<italic>r</italic> = 0.44; <italic>p</italic> &lt; 0.001), HOMA-IR (<italic>r</italic> = 0.47; <italic>p</italic> &lt; 0.001), triglyceride (TG) (<italic>r</italic> = 0.33; <italic>p</italic> = 0.003), high-density lipoprotein (HDL) cholesterol (<italic>r</italic> = -0.29; <italic>p</italic> = 0.008), and TyG index (<italic>r</italic> = 0.38; <italic>p</italic> &lt; 0.001). Multiple linear regression analysis indicated that plasma asprosin levels were independently associated with HOMA-IR (<italic>p</italic> &lt; 0.001) and TG/HDL cholesterol ratio (<italic>p</italic> &lt; 0.001).</p></sec><sec><title>Conclusions</title><p>This study demonstrated an association between plasma asprosin levels and obesity and insulin resistance in Korean children and adolescents.</p></sec>