Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1451954

Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study

Provisionally accepted
Xiao-Rong Wang Xiao-Rong Wang 1*Zeng Wu Zeng Wu 1,2Tong-Tong He Tong-Tong He 1Xiao-Han Chen Xiao-Han Chen 1*Xiao-Fei Jin Xiao-Fei Jin 1*Chun-Yue Zuo Chun-Yue Zuo 1Shao-Ze Yang Shao-Ze Yang 1*Yu Gao Yu Gao 1*Xiao-Hong Zhou Xiao-Hong Zhou 1*Wei-Juan Gao Wei-Juan Gao 1*
  • 1 Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
  • 2 Hebei University of Chinese Medicine, Shijiazhuang, China

The final, formatted version of the article will be published soon.

    Oxidative stress is widely acknowledged as a key pathogenic mechanism in diabetic nephropathy (DN). In recent years, the role of oxidative stress in DN has garnered increasing attention. However, no bibliometric analysis has yet been conducted on the relationship between oxidative stress and DN. This study aims to systematically analyze the relevant literature, identify trends in research, assess current hotspots, and predict future directions.We retrieved literature related to oxidative stress and DN from the Web of Science Core Collection database. We analyzed data on publication volume, countries/regions, institutions, journals, keywords, and other relevant metrics using VOSviewer, the Bibliometrix R package, and CiteSpace.From 2014 to 2024, a total of 4076 publications related to oxidative stress and DN were published across 755 journals, showing a consistent upward trend each year. China and the United States are the leading contributors in this field and demonstrate close collaborative efforts. The top contributors by country, institution, journal, and author include: China (1919 publications), Jilin University and Central South University (69 publications each), BIOMEDICINE & PHARMACOTHERAPY (117 publications), andProf. Sun Lin (33 publications). The most frequent keyword is "oxidative stress" (3683 occurrences). In the co-citation analysis, Alicic RZ's 2017 study was the most cited (144 citations). These findings highlight the critical importance of investigating the pathogenesis of DN from the oxidative stress perspective.This study demonstrates a steady increase in research on oxidative stress in DN since 2014, highlighting its central role in the pathogenesis of DN. Future research should focus on the molecular mechanisms of oxidative stress in DN and explore its therapeutic potential, to provide new strategies for the prevention and treatment of DN.

    Keywords: Diabetic nephropathy1, oxidative stress2, VOSviewer3, Bibliometrix R package4, CiteSpace5

    Received: 20 Jun 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Wang, Wu, He, Chen, Jin, Zuo, Yang, Gao, Zhou and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiao-Rong Wang, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Xiao-Han Chen, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Xiao-Fei Jin, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Shao-Ze Yang, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Yu Gao, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Xiao-Hong Zhou, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China
    Wei-Juan Gao, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China, Shijiazhuang, Hebei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.