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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1451758
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 22 articles

Elevated circulating homocysteine concentrations delaye nerve conduction velocity and increase the risk of diabetic kidney disease in Patients with Type 2 Diabetes

Provisionally accepted
Nannan Lv Nannan Lv 1*Luzhu Jia Luzhu Jia 2Fei Liu Fei Liu 1Lan Cheng Lan Cheng 1Feng Liu Feng Liu 1Jinsong Kuang Jinsong Kuang 1Xin Chen Xin Chen 2
  • 1 Other, Shenyang, China
  • 2 Department of Epidemiology, School of Public Health, Dalian Medical University, Dalian, China

The final, formatted version of the article will be published soon.

    China has the largest population of individuals with diabetes, and the prevalence of various complications among patients with type 2 diabetes in China remains high. Diabetic nephropathy affects approximately 20% to 40% of diabetic patients, becoming a major cause of chronic kidney disease and end-stage renal disease. Furthermore, around 50% of patients develop diabetic peripheral neuropathy (DPN), which is closely associated with physical disability, increased healthcare costs, and reduced work productivity. There is an urgent need for novel strategies in prevention, diagnosis, and treatment to improve patient outcomes. In this study, 163 patients with type 2 diabetes were selected as the observation group and further divided into three subgroups based on homocysteine (HCY) levels. The study measured several clinical parameters, including homocysteine, blood glucose, blood lipids, glycated hemoglobin, urinary microalbumin, urinary albumin-to-creatinine ratio (ACR), electromyography, and highly-sensitive C-reactive protein (CRP), among others. The levels of these indicators were analyzed and compared across the subgroups. The results revealed significant differences in uric acid, creatinine, urinary microalbumin, urinary ACR, and nerve conduction velocity (right tibial nerve sensory conduction) among different HCY levels in patients with type 2 diabetes (P < 0.05). Linear regression analysis indicated that homocysteine levels were associated with systolic blood pressure, glycated hemoglobin, fasting C-peptide, uric acid, creatinine, urinary microalbumin, and nerve conduction velocity (including motor conduction velocity of the ulnar nerve and sensory conduction velocity of the sural nerve). The clinical assessment of homocysteine in diabetic patients holds significant importance in the prevention of microvascular complications. Lowering HCY levels may offer a promising therapeutic approach for managing microvascular disease in diabetes.

    Keywords: Homocysteine, Nerve conduction velocity, Diabetic kidney disease, Diabetic peripheral neuropathy, type 2 diabetes

    Received: 19 Jun 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Lv, Jia, Liu, Cheng, Liu, Kuang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nannan Lv, Other, Shenyang, China

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