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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1451494
This article is part of the Research Topic Infertility and Endometriosis View all 18 articles

Non-High-Density to High-Density Lipoprotein Cholesterol Ratio and Its Association with Infertility in U.S. Women: A Cross-Sectional Study

Provisionally accepted
Yajie Zhang Yajie Zhang *Cong Lu Cong Lu *Lili Li Lili Li *Hongyu Li Hongyu Li *
  • Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

The final, formatted version of the article will be published soon.

    To investigate the relationship between Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) and infertility in US female adults aged 20 to 45. Our research team utilized data from the 2013–2018 National Health and Nutrition Examination Survey (NHANES) to conduct a cross-sectional study. Multivariable logistic regression was conducted to examine the association between NHHR and infertility, with trend tests providing additional insight into this relationship. Further, smoothed curve fitting was applied for a more detailed exploration. To ensure the robustness of our results, we conducted subgroup and sensitivity analyses. Between 2013 and 2018, our study included 2,947 participants, with 342(11.6%) self-reported infertility. A positive association was found between NHHR and infertility (OR=1.17,95%CI:1.07-1.27). Compared with the first trimester, the third trimester of NHHR was associated with an OR of 1.79(95% CI: 1.31–2.44) in model 3. The results of subgroup analyses revealed that the association between NHHR and infertility was nearly consistent. NHHR demonstrated a positive correlation with infertility among U.S. female adults. Further investigation is needed to explore their association better and the underlying mechanisms.

    Keywords: NHHR, NHANES, Cross-sectional research, Infertility, Women

    Received: 19 Jun 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Zhang, Lu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yajie Zhang, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Cong Lu, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Lili Li, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Hongyu Li, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

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