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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1448566

Association of trabecular bone score corrected for tissue thickness with glucose metabolism in acromegaly

Provisionally accepted
Martin Kužma Martin Kužma 1*Peter Vaňuga Peter Vaňuga 1,2Dušan Pávai Dušan Pávai 3Zdenko Killinger Zdenko Killinger 1Didier Hans Didier Hans 4Neil Binkley Neil Binkley 5Juraj Payer Juraj Payer 1Peter Jackuliak Peter Jackuliak 1
  • 1 Faculty of Medicine, Comenius University, Bratislava, Slovakia
  • 2 Dpt. of Endocrinology, National Institute of Diabetes and Endocrinology (Slovakia), Lubochňa, Slovakia
  • 3 Department of Endocrinology, National Institute of Diabetes and Endocrinology (Slovakia), Lubochňa, Slovakia
  • 4 Center of Bone Diseases, Lausanne University Hospital, Lausanne, Geneva, Switzerland
  • 5 Department of Medicine, University of Wisconsin Health, Madison, Wisconsin, United States

The final, formatted version of the article will be published soon.

    Acromegaly is associated with increased vertebral fracture (VF) risk regardless of bone mineral density (BMD). However, the vertebral trabecular compartment is still low; a possible contributor to this may be impaired glucose metabolism (GM) which frequently complicates acromegaly. Additionally, soft tissue thickness may confound bone imaging in acromegaly patients.Objectives To assess the association of GM with bone mineral density (BMD), trabecular bone score adjusted for BMI (TBSBMI), and for tissue thickness (TBSTT) among acromegaly subjects.Patients and methods: Cross-sectional study was performed of 70 consecutive acromegaly patients (24 males/46 females, aged 55.1 years) divided in two subgroups: abnormal GM (n=35) and normal GM (n=35). Using DXA, BMD, TBSBMI, TBSTT and VF screening was performed.Results: In all subjects, TBSTT was higher (mean 9.5%) than TBSBMI. Abnormal GM subjects had lower TBSBMI (1.166±0.15) than normal GM subjects (1.232±0.12; p<0.05). No between-group difference in TBSTT or BMD was observed. In a multiple regression model, the best predictor of TBSTT was HbA1c (p=.002). None of the DXA measures or GM parameters was significant predictor of VF (n=7).Abnormal GM acromegaly subjects had lower TBSBMI than those with normal GM.TBSTT wash higher than TBSBMI and no between-group difference based on GM status was observed TBSTT was significantly associated with GM parameters, notably HbA1c. The relationship of TBSTT with GM parameters may imply an effect of GM on trabecular bone microstructure in patients with acromegaly; further study is indicated.

    Keywords: Acromegaly, glucose metabolism, Trabecular bone score, Tissue thickness, Bone mineral dansity

    Received: 13 Jun 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Kužma, Vaňuga, Pávai, Killinger, Hans, Binkley, Payer and Jackuliak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Martin Kužma, Faculty of Medicine, Comenius University, Bratislava, Slovakia

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