Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1447984

Association between the triglyceride-glucose index and left ventricular myocardial work indices in patients with coronary artery disease

Provisionally accepted
Xuyang Meng Xuyang Meng 1Baoyu Feng Baoyu Feng 2Chenguang Yang Chenguang Yang 1Yi Li Yi Li 1Chenxi Xia Chenxi Xia 1Ying Guo Ying Guo 1Xiang Wang Xiang Wang 1*Fang Wang Fang Wang 1*
  • 1 Beijing Hospital, Beijing, China
  • 2 Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Triglyceride-glucose (TyG) index, as an effective surrogate marker of insulin resistance, has shown predictive value in the risk of heart failure in patients with coronary artery disease (CAD). This study aims to investigate the correlation between TyG index and myocardial work measurements in CAD, and to explore its role in detecting early subclinical cardiac dysfunction.: This cross-sectional study included 267 patients diagnosed with CAD and excluding left ventricular myocardial dysfunction in Beijing Hospital. Participants were divided into two groups according to the TyG index level, and myocardial work measurements were compared between groups. The correlation was explored between gradually increased TyG index and subclinical myocardial function in CAD patients. Results: We observed that TyG index was significantly correlated with the global waste work (GWW), and the value of GWW increased progressively with the elevation of TyG index. After adjusting for the effects of confounding factors, TyG index was still independently associated with GWW. Conclusion: An elevated TyG index was independently correlated with early subclinical myocardial dysfunction in CAD patients. Our study demonstrated that the strict control of TyG index may be conducive to forestall the progression of clinical heart failure in CAD patients.

    Keywords: Coronary Artery Disease, Triglyceride-glucose index, myocardial work, cardiac function, early subclinical cardiac dysfunction

    Received: 12 Jun 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Meng, Feng, Yang, Li, Xia, Guo, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiang Wang, Beijing Hospital, Beijing, China
    Fang Wang, Beijing Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.