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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1447184
This article is part of the Research Topic Cardiovascular Diseases Related to Diabetes and Obesity - Volume V View all 17 articles

Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome

Provisionally accepted
Leiyong Zhao Leiyong Zhao 1Chengjun Li Chengjun Li 2Hequn Lv Hequn Lv 1Chunli Zeng Chunli Zeng 1Peng Yongjun Peng Yongjun 1*
  • 1 Department of Acupuncture & Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
  • 2 Huangdao Hospital of Traditional Chinese Medicine, Qingdao, China

The final, formatted version of the article will be published soon.

    Background: Research on the association between blood glucose-related biomarkers and mortality has gained increasing attention. However, the association of hemoglobin glycation index (HGI) with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome has never been investigated. The objective of this study was to examine the association through a cohort study of the 2 American population.Methods: In this study, 8,267 participants were included. We utilized multivariable Cox regression analyses to explore the relationship between HGI and outcomes. The dose-response relationship between HGI and mortality was explored with restricted cubic splines. Recursive algorithms and segmented linear regression models were used to calculate the inflection points and assess the effect relationships before and after the inflection points.Results: In the model adjusting for all covariates, our analysis did not reveal a statistically significant association between HGI and mortality. Intriguingly, subsequent explorations of non-linear relationships unearthed a U-shaped correlation between HGI and both all-cause mortality and cardio-cerebrovascular mortality among American adults with metabolic syndrome. Before and after the inflection point, the HRs (95%CIs) for the association between HGI and all-cause mortality were 0.72 (0.63, 0.82) and 1.30 (1.17, 1.44), respectively. For cardio-cerebrovascular mortality, similar opposite relationships were found. The metabolic syndrome population with HGI levels at T2 had a lower rate of mortality.This cohort study of the American metabolic syndrome population highlighted a U-shaped association of HGI with all-cause and cardio-cerebrovascular mortality.

    Keywords: Hemoglobin glycation index, All-cause mortality, Cardio-cerebro vascular mortality, cohort study, metabolic syndrome

    Received: 11 Jun 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Zhao, Li, Lv, Zeng and Yongjun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Peng Yongjun, Department of Acupuncture & Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

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