Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1446390

Association of Stress Hyperglycemia Ratio with Presence and Severity of Chronic Kidney Disease Among US. Adults with Diabetes Mellitus

Provisionally accepted
Wenguang Lai Wenguang Lai 1Yaxin Meng Yaxin Meng 1*Yang Zhou Yang Zhou 2Tingting Zhang Tingting Zhang 1*Baoyuan Zhang Baoyuan Zhang 1*Zhidong Huang Zhidong Huang 3Zhiyong Gao Zhiyong Gao 1*
  • 1 Heyuan People's Hospital, Heyuan, Guangdong, China
  • 2 Southern Medical University, Guangzhou, Guangdong, China
  • 3 Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Background: Among diabetes mellitus (DM) patients, stress hyperglycemia ratio (SHR) is a strong predictor of short-and long-term prognosis, and adverse cardiovascular events. However, whether SHR is associated with increased risk of presence and severity of chronic kidney (CKD) disease remains undetermined.: Patients with DM from the National Health and Nutrition Examination Survey (NHANES) database (1999-2020) were included and divided into 5 groups according to their SHR level (quintile 1 to 5). Study outcomes were CKD, advanced CKD (ACKD), and CKD severity. Logistic regression and restricted cubic spline (RCS)were used to assess the association between the SHR and outcomes.Results: Totally, 6,119 patients were included. After adjustment, compared to patients with SHR in quintile 3 (as reference), the risk of CKD is 1.50 (P<0.001) for quintile 1, 1.23 (P=0.140) for quintile 2, 1.95 (P<0.001) for quintile 4, and 1.79 (P<0.001) for quintile 5. For the risk of ACKD, the OR is 1.46 (P=0.410) for quintile 1, 1.07 (P=0.890) for quintile 2, 3.28 (P=0.030) for quintile 4, and 3.89 (P=0.002) for quintile 5. For the CKD severity, the OR is 1.46 (P<0.001) for quintile 1, 1.20 (P=0.163) for quintile 2, 1.84 (P<0.001) for quintile 4, and 1.83 (P<0.001) for quintile 5. RCS analysis also showed a U-shaped association between SHR and outcomes (All P for nonlinearity<0.05).Our study demonstrated that too low or too high SHR level is significantly associated with adverse renal outcomes in patients with DM.

    Keywords: Stress hyperglycemia ratio, Diabetes Mellitus, Chronic Kidney Disease, chronic kidney disease severity, adverse renal outcomes

    Received: 09 Jun 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Lai, Meng, Zhou, Zhang, Zhang, Huang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yaxin Meng, Heyuan People's Hospital, Heyuan, Guangdong, China
    Tingting Zhang, Heyuan People's Hospital, Heyuan, Guangdong, China
    Baoyuan Zhang, Heyuan People's Hospital, Heyuan, Guangdong, China
    Zhiyong Gao, Heyuan People's Hospital, Heyuan, Guangdong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.