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REVIEW article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1445878

Effects of Different Supplements on Hashimoto's Thyroiditis: A Systematic Review and

Provisionally accepted
Bingcong Peng Bingcong Peng Weiwei Wang Weiwei Wang *Qingling Gu Qingling Gu *Ping Wang Ping Wang *Zhongyan Shan Zhongyan Shan *Weiping Teng Weiping Teng *
  • Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China

The final, formatted version of the article will be published soon.

    Clinicians often consider the use of dietary supplements to assist in lowering thyroid autoantibody titres in patients with Hashimoto's thyroiditis (HT). Currently, different supplements differ in their ability to reduce autoantibody levels. The purpose of this article is to compare the ability of different supplements to lower autoantibody titres and restore TSH levels through a systematic literature review. We obtained information from the PubMed, Web of Science, Embase, and Cochrane databases, as well as the China National Knowledge Infrastructure (CNKI). Selected studies included those using selenium, Vitamin D, Myo-inositol, and Myo-inositol in combination with selenium for the treatment of HT patients with euthyroidism. These data were combined using standardised mean differences (SMDs) and assessed using a random effects model. A total of 10 quantitative metaanalyses of case-control studies were selected for this meta-analysis. Compared to the placebo group, the use of selenium supplements was able to significantly reduce the levels of thyroid peroxidase autoantibodies (TPOAb) (SMD: -2.76, 95% CI: -4.50, -1.02) and thyroglobulin autoantibodies (TgAb) (SMD: -2.44, 95% CI: -4.19, -0.69). During a 6-month treatment, the use of Myo-inositol, Vitamin D alone, and the combination of selenium ,and Myo-inositol did not effectively reduce TPOAb

    Keywords: Vitamin D, Selenium, myo-inositol, Hashimoto's thyroiditis, Meta-analysis

    Received: 08 Jun 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Peng, Wang, Gu, Wang, Shan and Teng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Weiwei Wang, Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China
    Qingling Gu, Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China
    Ping Wang, Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China
    Zhongyan Shan, Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China
    Weiping Teng, Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.