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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1445787
This article is part of the Research Topic The Role of Metabolic Syndrome and Disorders in Cardiovascular Disease - Volume II View all 16 articles

Association between Cardiovascular Health Assessed by Life's Essential 8 and Hyperuricemia in U.S. Adults: the NHANES 2009-2020

Provisionally accepted
Meng Wang Meng Wang 1Heyu Meng Heyu Meng 2*
  • 1 Department of Computer and Simulation Technology, Faculty of Health Service, Naval Medical University, Shanghai, China
  • 2 China-Japan Union Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Background: This study presented the new Life's Essential 8 (LE8) framework for examining cardiovascular health (CVH) to analyze the potential relationship between the latter and hyperuricemia (HUA) in the U.S. population. Methods: Data on individuals aged at least 20 years were collected from the National Health and Nutrition Examination Survey (NHANES) 2009-2020. Smoothed curve fitting and multivariate logistic regression analyses were then performed on a sample of 25,681 adults to explore the association between LE8 and HUA. A sensitivity analysis was conducted to examine the robustness of the research findings. Results: The study found a strong negative association between LE8 and HUA, with an odds ratio (OR) of 0.71 and a 95% confidence interval (CI) from 0.69 to 0.73 after adjusting for multiple confounding factors. The sensitivity analysis further validated the robustness of this association. This analysis consistently showed negative associations across different genders, ages, races, and education levels (p < 0.05), but there were no significant relationships with marital status. The association between uric acid levels and LE8 displayed an inverted L-shaped curve, with an inflection point around 41.43. Conclusions: The findings indicate a strong negative relationship between LE8 and HUA among the U.S. population, suggesting that higher scores on the LE8, which assesses CVH, were associated with reduced uric acid levels. The consistent negative association underscores the LE8 framework's potential as a valuable tool for understanding and managing HUA in CVH.

    Keywords: Life's essential 8 1, Hyperuricemia 2, Cardiovascular health 3, NHANES 4, Crosssectional study 5

    Received: 08 Jun 2024; Accepted: 20 Aug 2024.

    Copyright: © 2024 Wang and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Heyu Meng, China-Japan Union Hospital of Jilin University, Changchun, China

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