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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Molecular and Structural Endocrinology
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1445712
This article is part of the Research Topic Pulmonary Fibrosis and Endocrine Factors View all 7 articles
Vitamin D metabolism-related single nucleotide polymorphisms in Chronic Obstructive Pulmonary Disease risk
Provisionally accepted
Susana Rojo-Tolosa
1,2
Laura Elena Pineda-Lancheros
3,4
Andrea Fernández-Alonso
3
Noelia Márquez Pete
3
Yasmin Cura
3
Cristina Membrive Jiménez
3
Luciana Maria Iglecias-Marangoni
3,5
MCarmen Ramírez-Tortosa
6
José María Gálvez-Navas
2,6,7,8*
Cristina Pérez-Ramírez
2,3,6
Concepción Morales-García
1
Alberto Jiménez-Morales
2,3- 1 Virgen de las Nieves University Hospital, Granada, Spain
- 2 Granada Biosanitary Research Institute (ibs.GRANADA), Granada, Spain
- 3 Department of Pharmacogenetics, Virgen de las Nieves University Hospital, Granada, Spain
- 4 Department of Pharmacy, Faculty of Sciences, National University of Colombia, Bogota, Colombia
- 5 Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil
- 6 Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain
- 7 Center for Biomedical Research in Epidemiology and Public Health Network, Carlos III Health Institute (ISCIII), Madrid, Madrid, Spain
- 8 Andalusian School of Public Health, Granada, Spain
Introduction: Chronic obstructive pulmonary disease (COPD) is one of the world's major public health problems. It is characterized by a major inflammatory response, where vitamin D, due to its role in regulating the immune system, and genetic variants involved in its metabolism may play an essential role. The aim of this study is to evaluate the association between 13 polymorphisms related to vitamin D metabolism and the COPD risk. Material and methods: A retrospective longitudinal study was designed in which 152 cases of COPD diagnosed at the University Hospital Virgen de las Nieves and 456 controls without the pathology, matched by age and sex, were included. The determination of the 13 polymorphisms was carried out using TaqMan™ probes. Results: Statistical analysis showed that the AA genotype and the A allele of the CYP27B1 rs4646536 polymorphism may be associated with an increased risk of developing COPD according to genotypic models (OR =
Keywords: chronic obstructive pulmonary disease, Vitamin D, Metabolism, Single nucleotide polymorphisms, biomarkers, risk
Received: 07 Jun 2024; Accepted: 14 Oct 2024.
Copyright: © 2024 Rojo-Tolosa, Pineda-Lancheros, Fernández-Alonso, Márquez Pete, Cura, Membrive Jiménez, Iglecias-Marangoni, Ramírez-Tortosa, Gálvez-Navas, Pérez-Ramírez, Morales-García and Jiménez-Morales. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
José María Gálvez-Navas, Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, 18071, Spain
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