Zhanli Wang
*
Hai Hu
The final, formatted version of the article will be published soon.
REVIEW article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1444940
This article is part of the Research Topic Epigenetic Modifications and Cardiovascular Diseases View all articles
Extracellular vesicular microRNAs and cardiac hypertrophy
Provisionally accepted- Baotou Medical College, Baotou, China
Cardiac hypertrophy is an adaptive response to pressure or volume overload such as hypertension and ischemic heart diseases. Sustained cardiac hypertrophy eventually leads to heart failure. The pathophysiological alterations of hypertrophy are complex, involving both cellular and molecular systems. Understanding the molecular events that inhibit or repress cardiac hypertrophy may help identify novel therapeutic strategies. Increasing evidence has indicated that extracellular vesicle (EV)-derived microRNAs (miRNAs) play a significant role in the development and progression of cardiac hypertrophy. In this review, we briefly review recent advancements in EV research, especially on biogenesis, cargoes and its role in cardiac hypertrophy. We then describe the latest findings regarding EV-derived miRNAs, highlighting their functions and regulatory mechanisms in cardiac hypertrophy. Finally, the potential role of EV-derived miRNAs as targets in the diagnosis and treatment of cardiac hypertrophy will be discussed.
Keywords: cardiac hypertrophy, Extracellular vesicle, microRNA, Inflammation, Regulatory mechanism
Received: 12 Jun 2024; Accepted: 23 Dec 2024.
Copyright: © 2024 Wang, Hu, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhanli Wang, Baotou Medical College, Baotou, China
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