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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1443734

Association between triglyceride-glucose index and gallstones: a cross-sectional study utilizing NHANES data

Provisionally accepted
Hongliang Li Hongliang Li 1Congfeng Zhang Congfeng Zhang 2*
  • 1 General Surgery, Dandong Central Hospital, Dandong, China
  • 2 Intensive Care Unit, Dandong Central Hospital, Dandong, China

The final, formatted version of the article will be published soon.

    This study used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the relationship between the triglyceride-glucose (TyG) index and gallstones.We evaluated the data collected between 2017 to 2020. To evaluate the relationship between TyG index and gallstones, logistic regression analysis, basic characteristics of participants, subgroup analysis, and dose-response curves were utilized.The study included 3891 participants over the age of 20 years, 419 of whom reported gallstones, with a prevalence rate of 10.8%. After adjusting for all confounding factors, the risk of gallstones increased by 55% for each unit increase in the TyG index (OR = 1.55, 95% CI: 1.09, 2.22). The dose-response curve also showed a positive correlation between the TyG index and gallstones. Subgroup analysis revealed a significant positive relationship between the TyG index and the risk of gallstones in those aged <50 years, women, individuals with total cholesterol levels > 200 mg/dL, individuals with body mass index (BMI) > 25.The risk of gallstones is positively correlated with a higher TyG index. Thus, the TyG index can be used as a predictor of the risk of gallstones.

    Keywords: gallstones1, triglyceride-glucose (TyG) index2, insulin resistance (IR)3, cross-sectional study4, NHANES5

    Received: 04 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Congfeng Zhang, Intensive Care Unit, Dandong Central Hospital, Dandong, China

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