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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1441878

Non-linear dose-response relationship between visceral adiposity index and diabetes in adults with normoglycemia: a cohort study

Provisionally accepted
Xiaomin Liang Xiaomin Liang 1Zemao Xing Zemao Xing 1*Ying Li Ying Li 1Shuiqing Gui Shuiqing Gui 1*Haofei Hu Haofei Hu 2*
  • 1 Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, China
  • 2 Department of Nephrology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China

The final, formatted version of the article will be published soon.

    Objective: Previous studies have identified a positive link with visceral adiposity index (VAI) and diabetes in specific populations. Our investigation focused on examining these associations among normoglycemic adults in Japan.A cohort study of NAGALA (NAfld in the Gifu Area Longitudinal Analysis) was undertaken from 2004 to 2015 in Japan. The link on VAI and diabetes was evaluated using multivariate Cox proportional hazards regression and restricted cubic spline (RCS) regression models.Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of VAI for incident diabetes.Results: Our study included 15,452 participants, with 8418 males (54.48%) and 7034 females (45.52%). The average age was 43.71 ± 8.90, and 373 participants (2.41%) developed diabetes. VAI is positively related to diabetes (HR=1.13, 95% CI 1.08-1.18). The inflection point of non-linear relationship was observed at a VAI of 4.67. For VAI values up to 4.67, a unit rise in VAI related to a 24% surge in new-onset diabetes (HR=1.24, 95% CI 1.12-1.37, p<0.0001). Subgroup analysis detected a more robust relation in females (HR=1.40, 95% CI 1.14-1.70, p=0.0010). ROC analysis indicated that VAI with an AUC of 0.7479 (95% CI: 0.7237-0.7720) had better predictive power.Our cohort study validated the positive and non-linear relations for VAI and diabetes among normoglycemic adults in Japan. The relevance was more marked for females than for males.By maintaining VAI below 4.67, a further reduction in VAI could potentially lead to a significant decrease in diabetes risk.

    Keywords: diabetes, visceral adiposity index, non-linear, Normoglycemia, cohort study

    Received: 31 May 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Liang, Xing, Li, Gui and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zemao Xing, Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, China
    Shuiqing Gui, Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, China
    Haofei Hu, Department of Nephrology, Shenzhen Second People's Hospital, Shenzhen, 518029, Guangdong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.