Skip to main content

REVIEW article

Front. Endocrinol.
Sec. Gut Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1441415

Intestinal flora and bile acid interactions impact the progression of diabetic nephropathy

Provisionally accepted
Jia Xu Jia Xu *Nan Wang Nan Wang Li Yang Li Yang Jing Zhong Jing Zhong Ming Chen Ming Chen *
  • Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    In recent years, with the rapid development of omics technologies, researchers have shown that interactions between the intestinal flora and bile acids are closely related to the progression of diabetic kidney disease (DKD). By regulating bile acid metabolism and receptor expression, the intestinal flora affects host metabolism, impacts the immune system, and exacerbates kidney injury in DKD patients. To explore interactions among the gut flora, bile acids and DKD, as well as the related mechanisms, in depth, in this paper, we review the existing literature on correlations among the gut flora, bile acids and DKD. This review also summarizes the efficacy of bile acids and their receptors as well as traditional Chinese medicines in the treatment of DKD and highlights the unique advantages of bile acid receptors in DKD treatment. This paper is expected to reveal a new and important potential strategy for the clinical treatment of DKD.

    Keywords: Diabetic kidney disease, intestinal flora, Bile acids, Farnesoid X Receptor, G protein-coupled bile acid receptor 1, Exosomes

    Received: 25 Jun 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Xu, Wang, Yang, Zhong and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jia Xu, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    Ming Chen, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.