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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1441090

Establishment of reference intervals of thyroid-related hormones for adults with normal liver function in Zhejiang Province by indirect method

Provisionally accepted
Xiying Huang Xiying Huang *Xufeng Yang Xufeng Yang *
  • Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

The final, formatted version of the article will be published soon.

    residents of coastal areas, focusing on extracting insights into the regional specificity of thyroid hormone levels. A thorough examination protocol was implemented, encompassing inquiries into thyroid health history, ultrasound screenings, palpations during thyroid surgery, detections of thyroid antibodies, and reviews of medication histories. Adherence to the CLSI C28-A3 guidelines(1-2) facilitated the derivation of RIs for thyroid-related hormones, subsequently juxtaposed against those provided by commercial entities.Results: The study delineated the following gender-and age-specific RIs for Thyroid-Stimulating Hormone (TSH): for males under 50 years, 0.57-3.37; males over 50 years, 0.51-4.03; females under 50 years, 0.53-3.91; and females over 50 years, 0.63-4.31. Further analysis revealed the RIs for Free Thyroxine (FT4), Free Triiodothyronine (FT3), Total Thyroxine (TT4), and Total Triiodothyronine (TT3) amongst males and females, with notable distinctions observed between the two genders and across age brackets. These findings are in stark contrast to the standardized intervals provided by manufacturers, particularly highlighting differences in TT3 and FT3 levels between genders and a tendency for TSH levels to increase with age.Conclusion: This research successfully establishes refined RIs for thyroid-related hormones within the Chinese coastal area populations, taking into account critical demographic factors such as gender and age. These tailored RIs are anticipated to significantly enhance the diagnostic accuracy for thyroid diseases, addressing the previously noted discrepancies with manufacturer-provided data and underscoring the importance of regionally and demographically adjusted reference intervals in clinical practice.

    Keywords: 129, Establishment of reference intervals, Zhejiang Province, adults with normal liver function, Thyroid-related hormones, Indirect method

    Received: 30 May 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Huang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiying Huang, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Xufeng Yang, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.