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REVIEW article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1440456

A Critical Review on Diabetes Mellitus Type 1 and Type 2 Management Approaches: From Lifestyle Modification to Current and Novel Targets and Therapeutic Agents

Provisionally accepted
Bantayehu A. Tegegne Bantayehu A. Tegegne 1*Adane Adugna Adane Adugna 2Aderaw Yenet Aderaw Yenet 1Wubetu Yihunie Wubetu Yihunie 3Yared Yibeltal Yared Yibeltal 1Abebe Dagne Abebe Dagne 1Zigale Hibstu Zigale Hibstu 2Gashaw A. Amare Gashaw A. Amare 2Desalegn Abebeaw Desalegn Abebeaw 2Haymanot Tewabe Haymanot Tewabe 4Rahel Belete Abebe Rahel Belete Abebe 5Tirsit K. Zeleke Tirsit K. Zeleke 1
  • 1 Department of Pharmacy, College of Medicine and Health Science, Debre Markos University Debre Markos, Ethiopia, College of Health Science, Debre Markos University, Debre Markos, Ethiopia
  • 2 Department of Medical Laboratory Science, College of Medicine and Health Science, Debre Markos University Debre Markos, Ethiopia, College of Health Science, Debre Markos University, Debre Markos, Ethiopia
  • 3 Department of Medical Pharmacy, College of Medicine and Health Science, Debre Markos University Debre Markos, Ethiopia, College of Health Science, Debre Markos University, Debre Markos, Ethiopia
  • 4 Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
  • 5 Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia

The final, formatted version of the article will be published soon.

    Diabetes mellitus (DM) has emerged as an international health epidemic due to its rapid rise in prevalence. Consequently, scientists and or researchers will continue to find novel, safe, effective, and affordable anti-diabetic medications. The goal of this review is to provide a thorough overview of the role that lifestyle changes play in managing diabetes, as well as the standard medications that are currently being used to treat the condition and the most recent advancements in the development of novel medical treatments that may be used as future interventions for the disease. A literature search was conducted using research databases such as PubMed, Web of Science, Scopus, ScienceDirect, Wiley Online Library, Google Scholar, etc. Data were then abstracted from these publications using words or Phrases like -pathophysiology of diabetes‖, -Signe and symptoms of diabetes‖, -types of diabetes‖, -major risk factors and complication of diabetes‖, -diagnosis of diabetes‖, -lifestyle modification for diabetes‖, -current antidiabetic agents‖, and -novel drugs and targets for diabetes management‖ that were published in English and had a strong scientific foundation. Special emphasis was given to the importance of lifestyle modification, as well as current, novel, and emerging/promising drugs and targets helpful for the management of both T1DM and T2DM.

    Keywords: Diabetes Mellitus, lifestyle modification, current antidiabetics, Novel drugs and targets, Probiotics, Phytomedicine

    Received: 29 May 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Tegegne, Adugna, Yenet, Yihunie, Yibeltal, Dagne, Hibstu, Amare, Abebeaw, Tewabe, Abebe and Zeleke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bantayehu A. Tegegne, Department of Pharmacy, College of Medicine and Health Science, Debre Markos University Debre Markos, Ethiopia, College of Health Science, Debre Markos University, Debre Markos, Ethiopia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.