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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Obesity
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1439901
This article is part of the Research Topic Endocrine and Metabolic Consequences of Childhood Obesity Volume III View all 14 articles

SPISE INDEX (Single Point Insulin Sensitivity Estimator): indicator of insulin resistance in children and adolescents with overweight and obesity. Tantari Giacomo 1 † ( ORCID 0009-0000-4881-5928), Bassi Marta (ORCID 0000-0002-9166-1079) 1-2 † , Pistorio Angela (ORCID 0000-0002-6895-8720) 3 , Minuto Nicola (ORCID 0000-0002-5280-6319) 1 , Napoli Flavia (ORCID 0000-0003-3567-6118) 1 , Piccolo Gianluca (ORCID 0000-0003-2815-6288) 4,5 , La

Provisionally accepted
Giacomo Tantari Giacomo Tantari 1Marta Bassi Marta Bassi 1,2Angela Pistorio Angela Pistorio 3Nicola Minuto Nicola Minuto 1Flavia Napoli Flavia Napoli 1Gianluca Piccolo Gianluca Piccolo 4Alberto La Valle Alberto La Valle 1Giordano Spacco Giordano Spacco 2Carla Cervello Carla Cervello 2Giuseppe D'Annunzio Giuseppe D'Annunzio 1*Mohamad Maghnie Mohamad Maghnie 1,2
  • 1 Department of Pediatric Clinic and Endocrinology, Giannina Gaslini Institute (IRCCS), Genova, Italy
  • 2 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child, School of Medical and Pharmaceutical Sciences, University of Genoa, Genova, Liguria, Italy
  • 3 Epidemiology and Biostatistic Unit, Giannina Gaslini Institute (IRCCS), Genoa, Italy
  • 4 Unità di Neuroncologia, Istituto Giannina Gaslini (IRCCS), Genova, Italy

The final, formatted version of the article will be published soon.

    Background: Insulin resistance in children and adolescents with obesity is linked to increased risk of type 2 diabetes mellitus and cardiovascular disease. The SPISE index, based on values of fasting triglycerides (mg/dL), HDL cholesterol (mg/dL), and BMI (kg/m2), shows promise in predicting insulin resistance in children.This study aimed to identify a SPISE cut-off for detecting insulin resistance and evaluate its relationship with pubertal development, anthropometrics, and glycometabolic profile in 232 children and adolescents, 155 males and 127 females (median age 13.2 years) with overweight (n=48) and obesity (n=184). SPISE index was calculated with the formula: 600 x HDL Cholesterol 0,185 /Triglycerides 0,2 x BMI 1,338 , and patients were categorized based on Tanner stages [(Group 1 (18.8%) Tanner 1, Group 2 (44.6%) Tanner 2-3-4, Group 3 (36.6%) Tanner 5)].Results: A SPISE cut-off ≤ 6.92 or ≤ 6.13 (based on the method used for insulin resistance detection), in subjects with Tanner stages I and II, showed good sensitivity and specificity as a marker of insulin resistance. SPISE index decreased significantly with the advancement of pubertal status (P < 0.0001) and with worsening severity of obesity (P < 0.0001).While no significant differences in SPISE marker were observed between patients with normal and abnormal glucose tolerance during OGTT within any pubertal stage, SPISE values were significantly lower in patients with confirmed insulin resistance (total sum of insulin OGTT  535µU/mL) in all three pubertal groups (Group 1: P=0.008; Group 2: P=0.0008 and Group 3: P=0.002, respectively).Conclusions: In children and adolescents with obesity the SPISE index can be proposed as an alternative to OGTT and other insulin-based methods for evaluating insulin resistance. Its advantage lies in using readily available and inexpensive laboratory tests, making it suitable for large-scale studies and follow-up monitoring across diverse populations.

    Keywords: Obesity, Overweight, Insulin Resistance, Type 2 diabetes mellitus Tipo di carattere: Non Grassetto Formattato: Inglese (Stati Uniti) Formattato: Colore carattere: Automatico Formattato: Colore carattere: Automatico Formattato: Tipo di carattere: Non Grassetto, Pediatrics

    Received: 28 May 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Tantari, Bassi, Pistorio, Minuto, Napoli, Piccolo, La Valle, Spacco, Cervello, D'Annunzio and Maghnie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Giuseppe D'Annunzio, Department of Pediatric Clinic and Endocrinology, Giannina Gaslini Institute (IRCCS), Genova, Italy

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