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MINI REVIEW article

Front. Endocrinol.
Sec. Gut Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1438066
This article is part of the Research Topic Insights in Gut Endocrinology View all 5 articles

Association between small intestine bacterial overgrowth and psychiatric disorders

Provisionally accepted
Bartosz Bogielski Bartosz Bogielski 1,2Katarzyna Michalczyk Katarzyna Michalczyk 2Piotr Głodek Piotr Głodek 2Bartosz Tempka Bartosz Tempka 2Wojciech Gębski Wojciech Gębski 2Dominika Stygar Dominika Stygar 1*
  • 1 Medical University of Silesia, Katowice, Poland
  • 2 Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze, Poland, Zabrze, Poland

The final, formatted version of the article will be published soon.

    Small intestinal bacterial overgrowth (SIBO) is a gastrointestinal condition characterized by abnormal colonization of bacteria in the small intestine, leading to overgrowth and alteration, which is linked to gastrointestinal issues, potentially affecting neurological and mental health. Despite existing research, we still do not understand how SIBO affects tryptophan metabolism and psychiatric diseases. We investigated the literature for connections between SIBO, tryptophan metabolism disruptions, and psychiatric disorders like autism, schizophrenia, Alzheimer's, and Parkinson's diseases. We also explored the interaction between thyroid disorders and their influence on SIBO and psychiatric illnesses. PubMed and Google Scholar databases were searched using keywords and phrases, individual and in combinations, like "SIBO," "gut microbiota," "neurologic disorders," "mental disorders," "tryptophan," "dopamine," and "thyroid disease." We focused on original research and review papers that presented empirical studies conducted on animal models and human subjects published in English between February 1992 to February 2023. The initial 2 634 534 records were preliminary screened based on title and abstract and then subjected to full-text review to exclude publications with insufficient data on SIBO, lack of a psychiatric disorder component, or methodological limitations compromising the integrity of the findings. The analysis highlights the significance of the association between psychiatric disorders and SIBO, emphasizing the role of gutmicrobial diversity in mental health. We advocate for more detailed studies, including longitudinal research, to clarify the causal relationships between SIBO, gut dysbiosis, and psychiatric disorders and for an integrated approach while treating complex psychiatric conditions.

    Keywords: gut-brain axis, Psychiatric disorder, SIBO, Small Intestine Bacterial Overgrowth, Thyroid disorder, tryptophan pathway

    Received: 24 May 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Bogielski, Michalczyk, Głodek, Tempka, Gębski and Stygar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dominika Stygar, Medical University of Silesia, Katowice, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.