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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1437711

The association between triglyceride-glucose index and gallstones: NHANES 2017-2020

Provisionally accepted
Li Gong Li Gong 1Shujin Fan Shujin Fan 2Zhenfei Peng Zhenfei Peng 1Zeyao Chen Zeyao Chen 3Yuzhou Liu Yuzhou Liu 4Yinluan Huang Yinluan Huang 4Chaofan Wang Chaofan Wang 5*Chunli Piao Chunli Piao 3*
  • 1 Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, Guangdong Province, China
  • 2 Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • 3 Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China
  • 4 Shenzhen Bao’an District Traditional Chinese Medicine Hospital, Shenzhen, China
  • 5 Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Objects: It remains unclear whether the triglyceride-glucose (TyG) index has correlations with gallstones. This study aimed to investigate the association between TyG index and gallstones. Methods: Data was obtained from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Participants who provided complete data about TyG index and gallstones were included in the analysis. Multivariable regression analysis and subgroup analysis were preformed to estimate the relationship between TyG index and gallstones. Restricted cubic splines (RSC) was employed to calculate the cut off value. Results: The TyG index was independently associated with gallstones and demonstrates a clear positive correlation (OR = 1.10; 95% CI: 1.01–1.21; p = 0.033). The threshold value is 8.98, showing a positive correlation between TyG index and gallstones when the TyG index is less than 8.98 (Log likelihood ratio P < 0.001). Subgroup analysis indicates that the correlation between TyG and gallstones is mainly observed in individuals with obesity, females, younger individuals, and those with normal blood sugar levels, with these subgroups all acting as mediators between TyG and gallstones. Conclusions: Higher TyG index was linked to a higher chance of developing gallstones. Managing insulin resistance (IR) could help reduce the risk of gallstones since the TyG index is an indicator of IR.

    Keywords: TyG index, Insulin Resistance, Gallstones, Cross-sectional, NHANES

    Received: 24 May 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Gong, Fan, Peng, Chen, Liu, Huang, Wang and Piao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chaofan Wang, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510000, Guangdong Province, China
    Chunli Piao, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China

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